Effectiveness of sesamol in alleviating neuroinflammation associated with Parkinson's disease

impairment with elderly people. The cytokines and chemokines network are very complex and participate to
balance the proinflammatory processes, apoptosis and cell existence. So, it is necessary to unravel the inflammatory
process in PD. Increased nuclear factor kappa B, expression of cytokines, increased activation of microglia
participate in the inflammatory process of PD. The activation of glial fibrillary acidic protein (GFAP) gene and
protein results in the activation of astroglial cells which ends up with neurodegeneration and central nervous
damage. Natural compounds carry a huge amount of antioxidant properties with health benefits and phenolic
compounds is a natural dietary source.
Methods: Quantitative determination of serum CRP, immunohistochemical study was carried out along with the
molecular studies such as (RT-PCR) and western blotting.
Results: Sesamol treatment decreased the C- Reactive protein level in serum of experimental animals. Sesamol
also increased the tyrosine hydroxylase cells in rotenone-induced animals. The gene and protein expressions of
NF-κB (p65), Tumor necrosis factor-α, cyclo oxygeanse-2, inducible nitric oxide synthase, interleukin-1β and
GFAP were also reduced in SES treated animals.
Conclusion: Sesamol served as an anti-inflammatory compound in ROT-induced animal model of PD. This work
mainly concentrates on the molecular mechanism of phenolic compound sesamol on rotenone induced PD.