Blood group genetics with special reference to the tribe’s health of Nagaland

India’s race, religion, and caste are quite diverse. Even within the same nation, regional variations exist in the ABO
blood type and the Rh system. The current research examined the relationship between diseases and the ABO blood
type among Nagaland’s Chakhesang ethnic communities. This research considered the population of sick people with ABO blood types. One hundred persons, including men and women from the Chakhesang tribe, served as research respondents. The Chakhesang Naga tribe was selected for this study because of the documented higher prevalence of hypertension and diabetes mellitus within this group compared to the broader regional population.
The study also aimed to explore a possible association between these health conditions and blood type A. The ABD
antisera typing Kit’s standard methodology was followed for blood group testing. S2 ABO software was used to
compute the Hardy-Weinberg model, and the chi-square test was used to compare the results. In this research, we
discovered that blood type A was more likely to develop hypertension and diabetes than blood types B and O (blood
type A, X2 =16.3, P =0.00*; blood type B, X2 =18, P =0.00*; blood type O, X2 =0.085, P =0.87). This might imply
that blood type A may be genetically predisposed to diabetes and hypertension more than other blood types. Our
research shows that, compared to healthy individuals, the prevalence of hypertension and diabetes was much higher
in the general population. The Chakhesang Naga tribe has the highest prevalence of blood type B, while those with
blood type A are the most afflicted and sensitive to hypertension and diabetes. A key limitation of the study is that the findings are based on a specific population and may not be generalizable. Larger and more diverse cohorts are
needed to evaluate their broader applicability.