Development and Optimization of Curcumin and Lycopene Mucoadhesive Buccal Patches Using Response Surface Methodology

ery for the systemic release of drugs because they give enhanced bioavailability by
bypassing hepatic first-pass metabolism and
allowing through the jugular vein, direct access
to the circulatory system. The present research
work is on the development and optimization
of a mucoadhesive buccal patch of curcumin
and lycopene for embattled release in oral cancer therapy. Using polymers like ethocel and
methocel, buccal patches were produced by the
solvent-casting method. Buccal patches were
evaluated by disintegration time, folding endurance, % drug release, surface pH study, swelling study, mucoadhesive strength and stability
studies. The developed buccal patches were
evaluated for cytotoxicity in KB cell line using
MTT assay. Folding endurance of formulation
was found to be 167.66. The disintegration time
of buccal patch was found to be 3.34 minutes.
Thus, it can be said that the oral cancer treatment using the buccal patch formulation that
has been created may be innovative.