Biocompatible Coatings for Pharmaceuticals

Om M. Bagade aDepartment of Pharmaceutics, Vishwakarma University School of Pharmacy, Pune-411048, Maharashtra, India ombagadepcist@gmail.com http://orcid.org/0000-0002-5398-2752 Priyanka E. Doke-Bagade bDepartment of Pharmaceutics, School of Pharmaceuticals Sciences, Vels Institute of Science, Technology & Advanced Studies (VISTAS), Chennai-600117 Tamilnadu, India http://orcid.org/0009-0002-0696-6896 Shrikaant Kulkarni cFaculty of Business, Victorian Institute of Technology, Melbourne, Australia dCentre for Research Impact & Outcome, Chitkara University, Punjab, India Biocompatible Coatings for Pharmaceuticals

The rapid advancement in pharmaceutical research has fueled the development of novel drug formulations and delivery systems to enhance therapeutic outcomes. Biocompatible coatings play a pivotal role in pharmaceuticals, offering a versatile platform to address challenges associated with drug stability, bioavailability, and patient compliance. This chapter systematically examines the current state of biocompatible coatings for pharmaceutical applications, focusing on their role in drug delivery and therapeutic efficacy. Additionally, nanotechnology has played a pivotal role in enhancing the performance of biocompatible coatings. The chapter begins by providing an overview of the key challenges in traditional drug formulations, emphasizing the need for innovative strategies to overcome limitations such as poor solubility, stability, and controlled release. Subsequently, it delves into various types of biocompatible coatings, including polymeric, lipid-based, and nanoparticle coatings, highlighting their unique properties and applications in drug delivery. Special attention is given to the mechanisms underlying enhanced drug delivery enabled by biocompatible coatings. This encompasses improved drug solubility, protection against enzymatic degradation, sustained release kinetics, and targeted delivery to specific tissues or cells. Case studies are presented to illustrate successful applications of biocompatible coatings in enhancing the pharmacokinetics and pharmacodynamics of diverse therapeutic agents. Furthermore, the review explores the biocompatibility and safety aspects of these coatings, addressing concerns related to cytotoxicity, immunogenicity, and long-term effects. The regulatory landscape for biocompatible coatings in pharmaceuticals is also discussed, providing insights into the approval process and current guidelines. The current knowledge of biocompatible coatings for pharmaceuticals provides a comprehensive understanding of their applications, mechanisms, and safety considerations. The insights presented herein contribute to the ongoing efforts to design innovative drug delivery systems that optimize therapeutic efficacy while ensuring patient safety.
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