Chapter 4 Drug delivery using mesoporous silica nanoparticles (MSNs): Drug Delivery, Catalysis and Sensing Applications

Mesoporous silica nanoparticles (MSNs) have emerged as a versatile and favorable platform for drug delivery, owing to their exceptional structural and chemical properties. This chapter explores recent developments in the design and application of MSNs as drug carriers, shedding light on their potential to transform the field of pharmaceuticals. MSNs possess an elevated surface area, tunable pore size, and promising biocompatibility, making them a paradigm contender for capturing and delivering a wide range of therapeutic agents. One significant benefit of MSNs lies in their capacity to accommodate a large range of pharmaceutical compounds, including both hydrophobic and hydrophilic drugs. This adaptability makes them a worthy option for drug delivery uses. Their well-defined porous structure not only protects the drug cargo from degradation but also allows for controlled release, enabling precise dosing and minimizing side effects. Moreover, the surface modification of MSNs allows for “targeted drug delivery,” enhancing therapeutic efficacy while minimizing off-target effects. In this comprehensive analysis, we discuss various strategies for loading drugs into MSNs, including physical encapsulation, covalent bonding, and surface functionalization. The study delves into the mechanisms governing drug release from MSNs, highlighting the factors influencing release kinetics. Additionally, it explores the safety and biocompatibility aspects of MSNs in drug delivery, addressing concerns related to toxicity and immunogenicity.