Advances in Liposome Technology: An Intensive Review of Formulation, Therapeutic Applications, and Challenges

Advances in Liposome Technology: An Intensive Review of Formulation, Therapeutic Applications, and Challenges Magendran Rajendiran https://orcid.org/0009-0008-6636-1200 Shanmugasundaram P Vetriselvan Subramaniyan Mahendran Sekar Neeraj Kumar Fuloria Shivkanya Fuloria Chinnaperumal Kamaraj Srikanth Jeyabalan Introduction:

Liposomes are versatile drug delivery vehicles due to their nanoscale lipid bilayer vesicles, capable of encapsulating both hydrophilic and hydrophobic substances. They have shown promise in vaccine development, gene therapy, cancer treatment, and targeted drug delivery. However, their clinical applicability is limited due to factors like drug stability, manufacturing constraints, regulatory challenges, and immune responses. This study explores liposome formulations by focusing on enhanced stability, robustness, and drug-loading efficiency. It also discusses therapeutic implementation challenges.
Methods:

A systematic literature review was conducted using specific keywords and Boolean operators across databases, such as Web of Science, PubMed, and Scopus. Non-peer-reviewed articles, conference abstracts, and studies with poor methodology were excluded.
Results:

This review highlights advances in liposome formulation that boost therapeutic performance, enhance stability, and improve drug loading. Despite their promise, clinical application depends on overcoming issues like manufacturing complexity, regulatory constraints, and immune reaction limitations.
Discussion:

Liposomes enable efficient encapsulation and targeted delivery for both hydrophilic and hydrophobic drugs, enhancing therapeutic efficacy. Their biocompatibility makes them effective in cancer therapy, vaccine transport, and gene delivery. Nevertheless, further research is needed to improve production processes and ensure long-term safety for regulatory approval and commercial scalability.
Conclusion:

Liposomes hold strong potential for medical use and drug delivery. To achieve broader clinical adoption, challenges in formulation and regulation must be addressed. This review highlights recent innovations and strategies to optimize liposome-based therapeutics.
07 04 2025 LiveAll1 10.2174/0115734080391666250605113411 https://www.eurekaselect.com/243357/article https://www.eurekaselect.com/243357/article