A review on advancement and usage of microneedle mediated drug delivery over years

One of the novel drug delivery systems is the transdermal drug delivery system. Currently transdermal delivery is one of the most promising methods for drug application. Transdermal drug delivery systems (TDDS) are defined as self-contained, discrete dosage forms which are also known as patches. There are many drawbacks to using conventional transdermal drug delivery techniques, such as needle phobia, which can be overcome by employing a transdermal patch mediated by microneedles, which has a quicker start of action, higher patient compliance, self-administration, and enhanced permeability. The microneedle (MNs) was first described as a novel method of drug delivery in 1998. Researchers have developed a refined technology using microneedles, which allow hydrophilic high molecular weight compounds to enter into the stratum corneum. Several medications, including anticancer medications, oligonucleotides, vaccines, proteins, DNA, and even nanoparticles, are interesting candidates for topical administration using microneedles.