Antioxidant and anticancer activity in leaf extracts of Elaeocarpus serratus (L.)

Research into new treatments and prevention measures is still needed since cancer is a serious worldwide
health concern. In this work, we used a number of in vitro tests to find out the antioxidant and anticancer
potential of ethyl acetate, chloroform, ethanol, and aqueous extracts from Elaeocarpus serratus (L).
Fresh leaves of E. serratus were gathered in January from Sugandhagiri in the Wayanad district of Kerala. For
antioxidant activity assessment, the ethyl acetate extract exhibited remarkable IC50 values of 54 µg/ml and
59 µg/ml in DPPH and ABTS radical scavenging assays, respectively, surpassing the ethanol, chloroform, and
aqueous extracts. In the case of anticancer activity, the ethyl acetate extract showed the highest efficacy
against MCF-7 cells, as evidenced by an IC50 value of 196.46 µg/ml. While the standard drug, doxorubicin,
exhibited superior anticancer activity with an IC50 value of 4.54 µg/ml, the ethyl acetate extract's performance
is noteworthy and highlights its potential as an anticancer chemical resource. In conclusion, this study's
findings suggest that E. serratus leaves have anticancer and antioxidant properties. This study lays the
groundwork for more research into the bioactive substances detected in the ethyl acetate extract, which
might have relevance for the creation of innovative medicines and goods high in antioxidants