Thiazole chalcones: Promising agents with diverse pharmacological properties

Hybrid molecules/combination of heterocyclic rings with natural and synthetic origins are a desirable
source for the creation of therapeutic agents. The chalcones are important biologically active heterocyclic
compounds which contain two aryl rings joined by a three-carbon ketovinyl group. Two significant
families of natural chemicals with a variety of pharmacological actions, thiazole and chalcone constitute
excellent building blocks for thiazole-chalcone hybrid, scaffolds as bioactive agents. Encouraged by the
promising medicinal application of such hybrids the scientific community has reported numerous thiazolechalcone hybrids with a wide spectrum of biological properties including anticancer, antimicrobial,
antidiabetic, antioxidant, antitubercular, and so on, through synthetic hybridization strategy. The present
review covers the development, the mechanisms of action as well as structure-activity relationships of
chalcone hybrids with potential therapeutic application for many ailments in recent one decade to assist
medicinal chemists for successful and effective development of thiazole-chalcone hybrids.