An overview of analytical methods for quantification of paracetamol

Both the international names paracetamol (used in Europe) and acetaminophen (used in the United
States) are official names in the case of the same chemical substance. In an attempt to exterminate worms
in the 1880s, two teenage physicians acetanilide was administered to a patient at the University of
Strasburg accidentally in place of naphthalene. They observed that even though the drug greatly lowered
high fever, it possessed very little impact on intestinal parasites. After a year, Frederick Stearns and Co.,
a division of Sterling Drug Inc., started offering 500 mg of aspirin pills over the counter in Great Britain
under the brand name panadol. A spectrophotometric approach based on continuous flow for detecting
paracetamol in pharmaceuticals is described. Created a stability-indicating technique to use the TLC
densitometry method to figure out how much paracetamol is in pharmaceutical preparations. An effective
approach for detecting acetaminophen in pharmaceutical formulations using reverse-phase highperformance liquid chromatography was developed. At a flow rate of 1.78 ml/min, a combination of
methanol and water (1:2 v/v) is employed with a C18 stationary phase, with spectrophotometric detection
193.3 nm. Created a method for determining paracetamol using differential pulse voltammetry at a
carbon ionic liquid electrode. A carbon paste electrode (CPE) and carbon ionic liquid electrode (CILE) were
both used to study how paracetamol behaves electrochemically in a 0.1 m acetate buffer solution (pH
4.6). For example, long-term alcohol abuse combined with concurrent usage of medications that cause
enzyme induction, including barbiturates, or carbamazepine, could make paracetamol poisoning more
likely