Type 2 Diabetes mellitus: Current prevalence and future forecast

It has been determined that diabetes mellitus is one of the four most significant non-communicable
illnesses, and as such, it requires immediate attention from all of the key stakeholders throughout the
world in an effort to reduce its prevalence and the difficulties that are connected with it. In light of the
consequences of hyperglycemia, as well as hyperglycemic-induced oxidative stress and inflammation, it is
regarded to be one of the top 10 major causes of mortality throughout the world, and it is responsible for
the deaths of around 1.6 million people each and every year. Additionally, it is regarded as the third most
significant risk factor for the premature death of people throughout the world. There is a significant
connection between hyperglycemia, hyperglycemic-induced oxidative stress, inflammation, and the onset
and progression of type 2 diabetes mellitus. Reports from a variety of sources have demonstrated that
persistent low-grade inflammation is connected to an increased chance of developing type 2 diabetes, and
that sub-clinical inflammation is a contributor to insulin resistance and is linked to the hallmarks of
metabolic syndrome, which include hyperglycemia. Both of these findings are consistent with one another.
The fundamental impetus behind the objective of this review was the relationship that exists between
diabetes, oxidative stress, and inflammation. By conducting large number of research work, numerous
traditional medicines have been found for diabetes. Extracts isolated from different natural resources
especially plants, have always been a rich arsenal for controlling and treating diabetes problem and
complication arising due to it. Therefore, the reader is able to have a better understanding of the
significance of the many different herbal and polyherbal formulations that have historically been used to
treat diabetes mellitus as a result of reviewing this article