Analytical methods of dutasteride: An overview

The synthetic 4-azasteroid dutasteride is authorized for the treatment of males with enlarged prostates
who have symptomatic benign prostatic hyperplasia. It is a competitive inhibitor of type 1 and type 2 of
5 alpha-reductase isoenzymes. The effectiveness of the drug as monotherapy or in conjunction with
tamsulosin, an alpha-adrenergic antagonist (a-blocker), has been shown in multiple open-label extensions
and randomized, double-blind, placebo-controlled trials. Dutasteride therapy is often well tolerated and
safe. Dutasteride is a well-researched used for the treatment of men who are infected by lower urinary tract
symptoms (LUTS) because it decreases the risk of acute urine retention and surgery belongs to benign
prostatic hyperplasia. Since dutasteride appears to lower the incidence of prostate cancer, it may also play
a part in the future as a chemopreventive medication.