Global Perspectives on Pharmacogenomics and Drug Discovery:

K. Rajakumari Vels Institute of Science, Technology, and Advanced Studies, India https://orcid.org/0000-0002-8102-9512 K. Kavinaya Shri Vels Institute of Science, Technology, and Advanced Studies, India https://orcid.org/0009-0003-4091-4341 R. Logesh Vels Institute of Science, Technology, and Advanced Studies, India https://orcid.org/0009-0004-0968-2762 S. S. Meenambiga Vels Institute of Science, Technology, and Advanced Studies, India https://orcid.org/0000-0002-5445-525X P. Vivek Vels Institute of Science, Technology, and Advanced Studies, India https://orcid.org/0000-0003-2088-7545 S. Ivo Romauld Vels Institute of Science, Technology, and Advanced Studies, India Global Perspectives on Pharmacogenomics and Drug Discovery

Pharmacogenomics, the study of how genes influence an individual's response to drugs, is changing the scene of medication disclosure and improvement by joining pharmacology and genomics to make powerful, custom-made to an individual's hereditary profile. This arising field is vital in customized medication, where medicines are upgraded in light of individual hereditary varieties. This chapter offers an in-depth exploration of the global impact of pharmacogenomics, underscoring key examination foundations and undertakings, moral contemplations, difficulties and future headings. The joint efforts exhibit the capability of joint endeavor to defeat difficulties and advance the field by fitting worldwide guidelines and creating strategies that help even-handed admittance to pharmacogenomic progressions are significant for the worldwide reconciliation of customized medication.
chapter 5 2024 12 13 123 166 10.4018/979-8-3693-6597-7.ch005 20250113024319 https://services.igi-global.com/resolvedoi/resolve.aspx?doi=10.4018/979-8-3693-6597-7.ch005 https://www.igi-global.com/viewtitle.aspx?TitleId=365452 10.1016/j.phrs.2024.107061 10.1001/jamahealthforum.2022.3451 10.3389/fonc.2020.00521 10.1007/s00439-021-02282-3 10.3325/cmj.2020.61.147 10.4324/9781315254517-12 Ethical implications in pharmacogenetics and pharmacogenomics. A.Butnariu 2015 41 Medical Connections. ButnariuA.SamascaG.LupanI. (2015). Ethical implications in pharmacogenetics and pharmacogenomics.Medical Connections., 10, 41–44. 10 10.1007/978-981-15-3895-7 10.1111/bioe.12285 10.2217/pgs-2020-0155 10.1016/j.gim.2024.101160 10.1186/s12915-020-00868-3 10.1002/cpt.1664 10.1002/cpt.2643 10.3390/genes12101511 Pharmacogenetic and pharmacogenomic discovery strategies. C.Crisafulli 2019 225 2 Cancer Drug Resistance (Alhambra, Calif.) CrisafulliC.RomeoP. D.CalabròM.EpastoL. M.AlbertiS. (2019). Pharmacogenetic and pharmacogenomic discovery strategies.Cancer Drug Resistance (Alhambra, Calif.), 2(2), 225.35582724 2 10.3389/fphar.2024.1463384 10.1177/2472555220982268 10.3390/ph17070881 Pharmacogenomics in Drug Research and Development D.Erceg 2024 439 Pharmacogenomics in Clinical Practice ErcegD. (2024). Pharmacogenomics in Drug Research and Development. In Pharmacogenomics in Clinical Practice (pp. 439–461). Springer International Publishing. 10.3390/ph17070881 10.3389/fphar.2023.1277561 10.2147/PGPM.S454328 10.1016/j.ajhg.2019.02.010 10.3390/jpm8010009 The ethical, legal and regulatory issues associated with pharmacogenomics: Systematically quantifying the literature. J. E.Hewitt 2018 782 3 Journal of Law and Medicine HewittJ. E. (2018). The ethical, legal and regulatory issues associated with pharmacogenomics: Systematically quantifying the literature.Journal of Law and Medicine, 25(3), 782–793.29978667 25 10.1186/s40246-023-00554-9 10.1186/s40246-023-00554-9 10.3390/jpm12030421 10.2217/pgs-2024-0026 10.3390/genes14101840 10.2217/pgs-2018-0008 10.1016/j.gene.2019.144050 10.1016/j.xphs.2017.04.051 10.1186/s40246-019-0229-z 10.1038/s41525-020-0119-2 10.1146/annurev-pharmtox-051921-091209 10.1016/j.jad.2024.05.063 10.3390/ijms21030969 10.1111/cts.12771 10.2217/pgs.15.9 10.1093/ehjcvp/pvab018 10.1093/ehjcvp/pvab063 10.1002/cpz1.189 10.1007/978-981-15-3895-7_12 . Miao, L., Zhang, J., Yi, L., & Huang, S. (2020). The ethical, legal, and regulatory issues associated with pharmacogenomics. Pharmacogenomics in Precision Medicine: From a Perspective of Ethnic Differences, 219-239. 10.1186/s40364-020-00213-4 10.3949/ccjm.87a.19073 10.58532/V2BS25P2CH5 10.1007/s00109-003-0496-x 10.1186/1744-8603-7-30 10.1186/s40246-021-00352-1 10.1038/s41576-022-00572-8 10.1038/s41576-022-00572-8 10.47957/ijpda.v12i1.580 10.3389/fphar.2023.1247088 10.1161/01.CIR.0000110626.24310.18 10.1124/pharmrev.122.000810 10.1016/j.euroneuro.2023.01.001 10.2147/PGPM.S35063 R.Shukla 2020 Pharmacogenomics: overview, applications, and recent developments ShuklaR. (2020). Pharmacogenomics: overview, applications, and recent developments. Drug Design-Novel Adv Omics Field Appl. 10.2217/pgs-2016-0153 . Sosa-Macías, M., Teran, E., Waters, W., Fors, M. M., Altamirano, C., Jung-Cook, H., ... & LLerena, A. (2016). Pharmacogenetics and ethnicity: relevance for clinical implementation, clinical trials, pharmacovigilance and drug regulation in Latin America. 10.1038/s41397-022-00272-w 10.2147/PGPM.S290781 10.3390/cancers14051131 10.3390/ijms242216077 10.1093/bib/bbab048 10.1007/978-981-15-3895-7_14 . Xiang, X., & Yuan, Y. (2020). Application of pharmacogenomics in drug discovery and development. Pharmacogenomics in Precision Medicine: From a Perspective of Ethnic Differences, 257-276. 10.3389/fphar.2024.1364135