Extended insights into the pathophysiological role of UBR5: a commentary

The recently published article by Wang et al. [1] in the
International Journal of Surgery has captured our attention. The authors have attempted to extensively discuss the structure and domain-specific functions of ubiquitin-protein ligase E3 compo- nent n-recognition 5 (UBR5). Besides, the authors discussed the pathophysiological role of UBR5, a histone ubiquitylation reg- ulator and a pivotal guard of DNA replication, in various dis- eases, including multiple cancers and neurological and viral diseases. However, their article falls short of exploring the pathological role of UBR5 in several critical diseases, including various cancers [e.g. urinary bladder cancer, testicular cancer, head and neck squamous cell carcinoma (HNSCC), Burkitt’s lymphoma, Hodgkin’s lymphoma], Alzheimer’s disease (AD), and severe acute respiratory syndrome coronavirus-2 (SARS- CoV-2) infection.