A REVIEW OF RECENT DEVELOPMENTS IN THE BIOLOGICAL ACTIVITY OF 1,3,4 THIADIAZOLES

A REVIEW OF RECENT DEVELOPMENTS IN THE BIOLOGICAL ACTIVITY OF 1,3,4 THIADIAZOLES P. Indhumathy R. Gandhimathi

The 1,3,4 thiadiazole ring's exceptional flexibility and wide range of therapeutic activity have made it an intriguing pharmacophore. This study clarifies the inherent characteristics of this five-membered heterocycle, emphasizing its polar and aromatic nature as well as its adaptability to changes that optimize its biological effect. We discuss the broad spectrum of pharmacological action that 1,3,4 thiadiazole compounds display, including antimicrobial, antifungal, antiviral, anticancer, and anti-inflammatory effects. Additionally, this study highlights the enormous potential for developing targeted medicines with improved effectiveness and selectivity and examines the intriguing possibilities of this flexible framework in the next drug discovery and development. Overall, this analysis highlights how important 1,3,4 thiadiazole is as a flexible pharmacophore that has the potential to completely change the field of medicine.
2024 2024 809 819 10.31788/RJC.2024.1738857 https://rasayanjournal.co.in/admin/php/upload/4258_pdf.pdf https://rasayanjournal.co.in/admin/php/upload/4258_pdf.pdf