Efficacy of Biogenic Zinc Sulfide NPs Against MCF-7 Breast Cancer Cells

Efficacy of Biogenic Zinc Sulfide NPs Against MCF-7 Breast Cancer Cells P. Aarthye Department of Physics, School of Basic Sciences, Vels Institute of Science, Technology and Advanced Studies, (VISTAS), Pallavaram, Chennai 600117, Tamil Nadu, India M. Sureshkumar Department of Physics, MepcoSchlenk Engineering College, Sivakasi, Virudhunagar 626005, Tamil Nadu, India https://orcid.org/0000-0003-3568-0918 Pandurangan Subash-Babu Department of Food Science and Nutrition, King Saud, University, Riyadh 11451, Saudi Arabia https://orcid.org/0000-0002-1910-274X Mohammad Z. Ahmed Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia Ayyaru Sivasankaran Department of Civil Engineering, Yeungnam University, Gyeongsan, 38541, South Korea Department of Bioengineering, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai, 602105, Tamil Nadu, India https://orcid.org/0000-0001-6281-9925

Green synthesis of nanoparticles through biogenic methods and plant secondary metabolites has gained significant importance due to their faster reduction rates, making them a more environmentally friendly and cost-effective alternative to traditional chemical and physical methods. This study presents a sustainable method for synthesizing fluorescent ZnS nanocrystals using Allium sativum extract. The synthesis utilizes sulfur-rich cysteine compounds and templating agents such as alkaloids and flavonoids of the Allium sativum extract. The resulting ZnS NPs were characterized using X-ray diffraction (XRD), UV–Vis spectroscopy, photoluminescence spectroscopy, while FE-SEM revealed an average particle size of 128 nm and TEM showed particle size in the range of 42–78 nm. The optical investigations reports showed that the biosynthesized ZnS NPs had an energy band gap of 4.9 eV with absorption and excitation wavelengths of 214 nm and 460 nm, respectively. In vitro cytotoxicity assays showed significant anticancer activity against MCF-7 human breast cancer cells, with an IC50 value of 58.2 [Formula: see text]g/mL.
This study produces fluorescent Zinc Sulphide (ZnS) nanoparticles using Allium sativum extract, with sulfur-derived cysteine compounds and alkaloids and flavonoids as templating agents. TEM analysis showed the nanoparticles had an average size of 128 nm. PL spectroscopy indicated a band gap of 4.9 eV, absorption at 214 nm, and emission at 460 nm. The ZnS nanoparticles demonstrated notable cytotoxicity against MCF-7 cells, with an IC50 value of 58.2 μg/mL, underscoring the eco-friendly nature of this synthesis method.
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