SYNTHESIS, CHARACTERIZATION, AND EVALUATION OF ANTIFUNGAL PROPERTIES OF SUBSTITUTED BENZIMIDAZOLE ANALOG

SYNTHESIS, CHARACTERIZATION, AND EVALUATION OF ANTIFUNGAL PROPERTIES OF SUBSTITUTED BENZIMIDAZOLE ANALOG Vijey Aanandhi M Anbhule Sachin J

Objective: The aim of the present study is to synthesize novel benzimidazole derivatives as potent antifungal agents.Methods: 2-chloromethyl-1H-benzimidazole has been synthesized by refluxing o-phenylenediamine with chloroacetic acid in the presence of 5N HCL. Further, N-substituted benzimidazole derivatives containing various heteroamines and aromatic compounds were synthesized. These, finally, prepared derivatives were kept for in vitro antifungal property.Results: A novel series of antifungal agents, containing benzimidazole nucleus as a basic skeleton, has been synthesized.Conclusion: The synthesized novel benzimidazole derivatives exhibit moderate activity (VMSA 1, 2, 8), some compounds showed significant activity (VMSA 6, 9, and 10), and compound VMSA 4 and 5 exhibits maximum activity.
12 28 2018 10.22159/ajpcr.2018.v11s4.31677 https://innovareacademics.in/journals/index.php/ajpcr/article/view/31677 https://innovareacademics.in/journals/index.php/ajpcr/article/viewFile/31677/16766 https://innovareacademics.in/journals/index.php/ajpcr/article/viewFile/31677/16766