Synthesis and Evaluation of In-vitro Anticancer Activity of Novel Pyrimidine Derivatives

A series of substituted 1-methyl-6-oxo-2-[(4-oxo-1,3-thiazolidin-3-yl)amino]-4-phenyl-1,6-dihydropyrimidine-5-carbonitrile were synthesized by multicomponent type of reaction using ethyl cyanoacetate, thiourea and aromatic aldehyde. The anticancer potential of every produced substance were evaluated through HT29 and A549 cell lines. In the given series, compounds 7m and 7r showed the highest anticancer potential on HT29 and A549 cell lines with IC50 of 10.0 and 17.2 µg/mL. The in-silico ADME of 7m and 7r showed good pharmacokinetic properties.