Synthesis, Characterization, and Biological Evaluation of a Titanium-Based Amino- Functionalized MOF/Graphene Oxide Composite: Antibacterial Activity and Drug Delivery Potential

In this study, we synthesized and extensively characterized of graphene oxide amino-
functionalized metal-organic frameworks (MOFs), TTIP-H 2 BDC-NH 2 /GO and using Ti as
the metal source. These MOFs were employed for biological applications, offering a cost-
effective and affordable technique in the energy sector due to their synthesis from inexpensive
and accessible metal salts and ligands. Characterization via UV, FTIR, Raman, PXRD, TGA,
and FESEM confirmed the formation of TTIP-H 2 BDC-NH 2 /GO Under optimized
conditions, high- quality MOFs were produced. Notably, the Ti-MOF-GO composite exhibited
a Z-scheme heterojunction structure. The Ti-based MOFs demonstrated unique antibacterial
capabilities, making them promising candidates for drug delivery applications. The Ti-MOF
composite showed significantly improved antibacterial ability with low cytotoxicity. Further
density functional theory investigations explained the favorable biological effects. This study
paves the way for developing Ti-MOF composites with antibacterial and anti-inflammatory
properties for enhanced drug release applications