Fabrication and Characterization of Sulforaphane Loaded Magnetic Nanoparticles

Objective: The purpose of the present
research work was to develop Sulforaphane loaded
magnetic nanoparticles (MNPs) and the effect of prepared
magnetic nanoparticle on the enhancement of
bioavailability, stability, and dissolution was studied.
Sulforaphane (SFP) is a naturally occurring isothiocyanate
and chiefly available in broccoli. Methods: Magnetic
Nanoparticles were prepared by encapsulating herbal drug
SFP with iron salts and the prepared magnetic
nanoparticles were analyzed by Infrared Spectroscopy,
Crystal Analysis, Scanning Electron Microscope (SEM),
Thermal Analysis, Drug Loading Efficiency, Magnetic
Analysis, Electrical Analysis and Stability Studies. Results:
The obtained data of the characterization studies reveal that
the magnetic nanoparticles (MNPs) have good holding
properties. The particles sizes of MNPs measured from
High Resolution Scanning Electron Microscopy (HRSEM)
were of ideal size range 100 - 250 nm and showed a regular
pattern of spherical shape. The Vibrating Sample
Magnetism (VSM) results showed that satisfactory value.
The pH of the medium has an inverse relationship with the
amount of Sulphoraphane released by the MNPs.
Conclusion: From the results, the current study concludes
that the prepared MNPs (four types) are structurally
arranged following a good pattern, sufficient amount of
elements with good size range over the particle surface, and
exhibit magnetic responsiveness which is sufficient for
drug target due to an external magnetic field because of its
pore volume and large surface area. Dissolution study
reveals that the prepared Sulforaphane loaded MNPs of
Iron-MCM-41 showed maximum drug release at pH 5.5.