TARGETED NANOFORMULATIONS OF PHYTOCHEMICALS IN IBD MANAGEMENT

ABSTRACT
Inflammatory bowel disease (IBD) is an idiopathic disease, that affect the GIT, especially the colon and ileum regions. It can be classified into Crohn's disease and ulcerative colitis, which are among the chronic GI diseases with unknown pathogenesis. Conventional treatments for IBD include biologics, corticosteroids, and immunomodulators which are often limited due to side effects, overall systemic toxicity and decreased patient compliance. Hence, the reguirement of selective and site-specific routes of drug delivery to the inflamed location of the colon remain of high importance.Various in vitro and in vivo researches and studies have been performed and recorded to demonstrate that phytochemicals and natural macromolecules from plants like curcumin, resveratrol, quercetin, and green tea reduce IBD-related complications. As a result., Nano-formulations are extensively researched. Here, nano-formulation strategies offer a promisinp solution by encapsulation of drug within polymeric nanoparticles, lipid carriers, nano emulsions, and hydrogel systems, thereby improving stability, targeted colonic delivery, and controlled release.the future of IBD and Nanotechnology must aim optimization of carriers, and conducting and executing successful and well researched clinical trials to ensure that the nano formulation is safe.efficacious and shows a long- term therapeutic potential.
KEY WORDS: Crohn's disease, Ulcerative colitis, Inflammatory bowel disease, Curcumin,
Resveratrol, Nanotechnology, Nano-formulations, Phytochemicals, Colonic delivery