NEXT GEN ADVANCEMENT IN GREEN CHEMISTRY RELATED TO PHARMACEUTICAL ANALYSIS

Green Analytical Chemistry (GAC) is reshaping pharmaceutical quality control (QC) by promoting approaches that minimize environmental impact while maintaining analytical precision. Traditional QC methods, such as high-performance liquid chromatography (HPLC) and gas chromatography (GC), often depend on large volumes of hazardous organic solvents and generate substantial chemical waste, contributing to environmental pollution and increased operational costs. GAC addreses these issues through the development and implementation of sustainable analytical practices, such as utilizing biodegradable or less toxic solvents, adopting miniaturized and automated techniques like microextraction and capillary electrophoresis, and incorporating energy-efficient technologies, including ultra-high performance liquid chromatography (UHPLC). These strategies significantly reduce solvent consumption, waste generation, and energy usage in QC laboratories. Additionally, GAC aligns with the prineiples of green chemistry and the broader goals of sustainable development, supporting safer laboratory environments and regulatory compliance. This review discusses the transformation of QC laboratories through GAC, with attention to greener sample pretreatment and chromatographic methods, highlighting real-world examples and quantifiable successes in reducing the ecological footprint of pharmaceutical analysis. Overall, GAC offers a pathway towards more responsible, efficient, and sustainable quality control in the pharmaceutical industry.
Kev words: Green Analvtical Chemistry (GAC) .Ouality Control (OC) .Eco-friendl Analysis, Chromatography, HPLC (High-Performance Liquid Chromatography).