Beyond Blood Sugar: An AI-Driven Lifestyle Assessment Tool for Estimating Type 2 Diabetes Risk in Young Adults

Transdermal Drug Delivery Systems (TDDS) are widely used because they are easy to
administer, improve patient compliance, and provide controlled and sustained drug release
with fewer systemic side effects. However, the main limitation of TDDS is the poor
permeation of drugs through the skin. The outermost skin layer, the stratum corneum, acts as
a strong protective barrier that restricts the penetration of many drugs.
To overcome this challenge, researchers have developed nanocarrier-based drug delivery
systems. Among these, dendrimers have gained significant attention. Dendrimers are highly
branched polymeric nanostructures with a well-defined architecture, allowing high drug
loading capacity, improved solubility, and enhanced skin permeation. Their unique structure
also enables better interaction with biological membranes, making them effective carriers for
transdermal drug delivery.