INTEGRATING ADVANCED THERAPEUTICS FOR DRUG-RESISTANT EPILEPSY: GENE THERAPY, AI INNOVATIONS, AND NEUROPROTECTIVE STRATEGIES

This studyaims toexplore theintegration of innovative technologies in the
treatment of drug-resistant epilepsy, focusing on three major advanced
techniques: gene therapy, use of artificial intelligence (AI), and advanced
brain stimulation techniques. Gene therapy such as neuropeptide Y and
galanin have been demonstrated in preclinical studies to have a positive
effect on seizure activity. Efficient delivery of a transgene to target neurons
also constitutes part of a successful gene therapy-based treatment. Ad
vances have been made in the areas of cell transplantation and in the
development of recombinant viral vectors for gene delivery. rAAV vectors
gene therapy of neurological disorders owing to their neuronal tropism,
lack of toxicity, and stable persistence in neurons, resulting in robust long
term expression of the transgene. offers potential for curative treatments
through both gene editing and viral vectors.
AI advancements promise to revolutionize seizure management by pre
dicting risks, personalizing treatment, and promoting nerve regeneration.
such as VNS therapy, mjn-SERAS AI algorithm
The role of novel anticonvulsants drugs, including brivaracetam, Lamo
trigine and Cenobamate, in seizure control and neuroprotective properties
in neurological well-being is reviewed. Current brain stimulation tech
nologies and emerging techniques aim at enhancing seizure control and
preventing long-term neural damage.
Research Category and Technology and Methods
Clinical Research: 22. Neuropharmacology
Keywords
brain stimulation techniques, novel anticonvulsants, Gene therapy, long
term neural damage