GO/Fe₃O₄ Based Magnetic Polymer Composite for Advanced Drug Delivery Applications

GO/Fe₃O₄ Based Magnetic Polymer Composite for Advanced Drug
Delivery Applications
J. Ragaboth and Shanmuga Priya V*
Department of Chemistry, School of Basic Sciences, Vels Institute of Science Technology &
Advanced Studies, Pallavaram- 600117, Tamil Nadu, India
*corresponding author: shanmugapriyavimalan@gmail.com
Abstract
Developing efficient drug delivery systems is essential for improving targeted therapy
and minimizing side effects. In this study, a magnetic nanocomposite consisting of graphene
oxide (GO), iron oxide (Fe₃O₄), pectin, and polyvinyl alcohol (PVA) was synthesized for
controlled drug delivery applications. Graphene oxide provides a high surface area and
functional groups for effective drug loading, while iron oxide nanoparticles impart magnetic
properties for targeted delivery. The biopolymer matrix of pectin and PVA offers
biocompatibility, mechanical stability, and pH-responsive behaviour. The composite beads
were prepared through ionic crosslinking, forming a stable and biodegradable drug carrier
system. The synergistic interaction of GO, Fe₃O₄, and polymer components enhances drug
loading efficiency and enables controlled and sustained drug release. This multifunctional
system demonstrates promising potential for magnetically guided and site-specific drug
delivery applications.
Keywords: Graphene Oxide; Iron Oxide Nanoparticles; Magnetic Drug Delivery; Controlled drug release