“IVIG: A Key Therapy for Autoimmunity”

Intravenous immunoglobulin (IVIG) is a pooled antibody, and a biological agent used to manage various
immunodeficiency states and a plethora of other conditions, including autoimmune, infectious, and
inflammatory states. IVIG: is a sterile, highly purified preparation of these antibodies (mainly IgG) from the
plasma of thousands of donors. Autoimmune disorders are conditions where the immune system mistakenly
damage its own body cells, tissues and organs. Which leads to a chronic inflammation, tissue damage and
affects the normal function of the body. IVIG works by supplying the body with healthy antibodies that help
control an overactive immune system. It blocks harmful autoantibodies, reduces inflammation, and balances
immune responses. In this way, it protects the body from attacking its own cells. include neutralization of
pathogenic autoantibodies, modulation of Fc receptors, inhibition of complement activation, and regulation
of cytokine networks. Clinically, IVIG has proven that effective against the disorders like Guillain–Barré
syndrome, myasthenia gravis, immune thrombocytopenia, Kawasaki disease, dermatomyositis, and certain
neurological disorders, and chronic inflammatory demyelinating polyneuropathy (CIDP). Even though
Intravenous immunoglobulin is safe and beneficial but it has some limitation like they are expensive,
insufficient supply meanwhile they have some side effects like headache, flushing, severe allergic reaction
and kidney failure. Still, for patients who do not respond to other treatments, but IVIG provides significant
improvement in symptoms and quality of life. The research and clinical studies shows that, IVIG continues
to developed in the field of autoimmune disorders.