NANOFIBER SCAFFOLDS FOR DRUG DELIVERY IN TISSUE REGENERATION

Tissue damage caused by trauma, chronic diseases, or surgical interventions remains a major
challenge in modern healthcare. Conventional drug delivery methods often fail to provide sustained
and localized therapeutic effects at the damaged tissue site. Nanotechnology-based approaches,
particularly nanofiber scaffolds, have emerged as promising platforms for enhancing drug delivery
and supporting tissue regeneration.Nanofiber scaffolds mimic the natural extracellular matrix (ECM)
structure, providing a suitable environment for cell attachment, proliferation, and differentiation.
Their high surface area, porosity, and tunable physicochemical properties allow efficient loading and
controlled release of therapeutic agents such as growth factors, antibiotics, and anti-inflammatory
drugs. These properties make nanofiber scaffolds highly suitable for regenerative medicine
applications.Nanofiber scaffolds were fabricated using the electrospinning technique with
biocompatible polymers such as polycaprolactone and gelatin. Therapeutic agents were incorporated
into the nanofibers during the fabrication process to enable sustained drug release. The scaffolds were
characterized using scanning electron microscopy for morphology, drug loading efficiency tests, and
in-vitro drug release studies. Cell viability and proliferation assays were conducted to evaluate
biocompatibility and regenerative potential.The fabricated nanofiber scaffolds exhibited uniform fiber
morphology, high drug encapsulation efficiency, and controlled drug release over an extended period.
In-vitro studies demonstrated improved cell adhesion, proliferation, and enhanced tissue regeneration
potential compared with conventional drug delivery systems. Nanofiber scaffolds represent a
promising strategy for localized and sustained drug delivery in tissue regeneration. Their biomimetic
structure and controlled release capability may significantly improve therapeutic outcomes in
regenerative medicine and advanced drug delivery systems.