Beyond Blood Sugar: An AI-Driven Lifestyle Assessment Tool for Estimating Type 2 Diabetes Risk in Young Adults

Introduction: Parkinsons Disease is a neurodegenerative brain disorder that progresses slowly in most people. It has characterized by degradation of dopamine-carrying neurons in the substantia nigra. The main aim of the Present study is to Formulate and evaluate hecogenin loaded Phycocyanin nanospong es against Parkinsons Disease. Methodology: Docking studies were Performed with MAO B and Synuclein against Hecogenin, Factorial Design by Box Behnken Design for optimization of hecogenin loaded Phycocyanin nanosponges, Formula
tion of nanosponges by Solvent Diffusion method and Charecetriztion of formulated nanosponges by FTI
R, XRD, SEM, DSC, and Invitro Drug release Studies.
Result: Docking Scores of Hecogenin, Moldock score -128.46 compared with levodopa moldock score -10
0.80. Optimization results shows that F4 (Drug polymer ratio 1:2) is the best formulation with particle size 193±4.6 nm, Zetapotential 32.2±1.4 mV, Polydisperse index 0.12±0.6, Entrapment efficiency 88.5±1.6%, P
ercentage Drug release 80.5±2.4. with the optimization result best formulation were prepared by Solvent dif
fusion method and performed characterization by FTIR shows drug and polymer has good Compatibility. S
EMImages shows well defined particles (Particle size ~193 nm), XRD analysis confirms successful transfor
mation of crystalline hecogenin to Soluble Amorphous form. DSC analysis Confirms amorphization of Hecogenin within the nanosponge matrix, enhancing solubility and stability. Invitro drug release shows 80.5 % of drug release. In -vivo studies are under Progress.