BIOAVAILABILITY ENHANCEMENT USING NOVEL DRUG DELIVERY SYSTEM

Bioavailability is an important pharmacokinetic parameter that refers to the rate and extent to
which a drug reaches the systemic circulation Many drugs shopoorbioavailability due to low
solubility, poorpermeability, and extensivefirst-passmetabolism. This can reduce the
therapeutic effectiveness of the drug. To overcome these limitations, various novel drug
delivery systems (NDDS) have been developed to enhance drug solubility, stability, and
absorptionNovel approachessuchasnanoparticles, liposomes, nanoemulsions, solid
dispersions, and polymeric drug delivery systems are widely used to improve the
bioavailability of poorly soluble drugs. These systems increase the surface area of the drug,
enhance dissolution rate, and promote better absorption in the gastrointestinal tract. As a
result, they improve therapeutic efficiency and reduce the required dosage and side
effectsThis project focuses on the concept of bioavailability enhancement using novel drug
delivery systems and highlights the importance of advanced formulation techniques in
improving drug delivery and pharmacokinetic performance
keyword:
Bioavailability, Novel Drug Delivery Systems(NDDS), Drug Absorption ,Solubility Enhancement
,Nanoparticles, Liposomes, Nanoemulsion, SolidDispersion, Pharmacokinetics, delivery Systems.