PHARMACOKINETICS OF NOVEL DRUG DELIVERY SYSTEM

Abstract:
Paeonol is a type of phenol that has biological activity. lIt can be found in a number of different
sources,including the plant Dioscorea japonica, as well as some varieties of the Paeonia plant
(specifically Paeonia suffruticosa and Paeonia lactiflora). In addition to being found in these plants,
there has been a lot of research conducted regarding the pharmacological effects of paeonol.
The purpose of this research is to review the chemistry, pharmacokinetics, pharmacological effects,
and some of the formulations of paeonol.We have searched several different scientific databases (e.g,
PubMed, Scopus, and ProQuest)for the term "paeonol" and have reviewed all papers related to this
term. We have searched the scientific literature published from 1969 through 2019 Researchers have
synthesized several different derivatives of paeonol (methoxy,ethoxy,piperazine,
chromonylthiazolidine, phenol-phenylsulfonyl, alkyl ether, aminothiazole, and tryptamine) that
enhance the stability of paeonol. They have also evaluated these derivatives for various In vitro
biological activities e.g.., anti-inflammatory, tyrosinase Inhibitory, neuroprotective, anticancer, and
antiviral). Even though paeonol has multiple potential uses as a therapeutic agent, has not been widely
used clinically due to S poor water solubility, low oral bioavailability, low stability, and high
volatility when exposed to room temperature. To increase the bioavailability of paeonol, researchers
have createdvariousformulations that can be used to deliver paeonol and have evaluated the
pharmacological activity of these formulations; these formulations of paeonol can be classified In
several ways (e.g, conventional formulations (tablets, topical gels, and hydrogels); polymeric delivery
systems (microparticles,microsponges, dendrimers, nanocapsules, polymeric nanoparticles, and
nanospheres); and lipid-based delivery systems, liposomes,delivery systems (microemulsions, selfmicro-emulsifying drug transethosomes, ethosomes,niosomes, and proniosomes)
Key words
Paeonol, phenolic compound, biological activity, Dioscorea japonica, Paeonia suffruticosa,Paeonia
lactiflora,pharmacology, chemistry, pharmacokinetics, anti-inflammatory activity, tyrosinase