3D-Printed Pharmaceuticals: Customized Dosing, Polypills, and On-Demand Drug Manufacturing :Review article

3D printing, or additive manufacturing, has revolutionized multiple industries, and its
application in pharmaceuticals offers promising avenues for personalized medicine. This review
explores recent advancements in 3D-printed pharmaceuticals, emphasizing customized dosing,
polypill formulations, and the potential for on-demand drug manufacturing. These innovations aim to
enhance therapeutic outcomes, improve Additive manufacturing or 3D printing has the potential to
revolutionize the pharmaceuticals sector by facilitating the feasible implementation of personalized
medicine. The capability to customize a medication's dose to meet a patient's unique requirements
e.g., for pediatric, geriatric, or pharmacogenomics-guided therapy
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remedies an essential weakness
of the conventional "one-size-fits-all" model, and could increase therapeutic effectiveness and
safety. The potential for decentralized, demand-based manufacturing in pharmacies or even
hospitals could change supply chains, enabling instant production of individual drugs or customized
formulations according to urgent clinical demand. In spite of this encouraging potential, however,
the general clinical use of 3D-printed medicines is currently confronted by significant challenges.
Among these are the creation of a robust regulatory environment for decentralized production,
assuring scalability of the printing process, and broadening the library of pharmaceutically-approved,
biocompatible printing materials. This review meets these challenges by highlighting the compelling
opportunities they create for future science, technology development, and integration into the
mainstream of clinical practice. dication adherence, and facilitate decentralized production.
Challenges such as regulatory hurdles, scalability, and material constraints are also discussed, along
with prospects for future research and clinical implementation.