NANOTECHNOLOGY-BASED DRUG DELIVERY SYSTEMS FOR IMPROVING SOLUBILITY AND BIOAVAILABILITY OF POORLY SOLUBLE DRUGS

Nanotechnology has been recognized as a promising tool to address the issues of solubility and bioavailability of poorly soluble drugs, especially BCS Class II and Class IV drugs. Poor aqueous solubility can act as a barrier to the absorption of the drug, thus affecting its therapeutic efficacy. In the present study, different nanoscale drug delivery systems (NDDS) have been explored to overcome the problems associated with poorly soluble drugs. These include lipid-based nanocarriers, polymeric nanoparticles, Nano emulsions, nanogels, and inorganic nanocarriers. These nanoscale drug delivery systems have been shown to improve the solubility, stability, and absorption of the drug, thus improving therapeutic efficacy while reducing adverse effects. Emphasis was given to the role of nanoparticle size, surface modification, and their importance in improving the efficiency of drug delivery. Optimizing all the parameters can help in achieving targeted drug delivery, thus improving therapeutic efficacy. Recent advancements in nanotechnology have greatly contributed to the development of efficient drug delivery systems for poorly soluble drugs. Certain limitations, including high production costs and potential hazards, also need to be taken into consideration. Nanotechnology can thus be regarded as a promising and innovative tool in pharmaceutical engineering, providing new avenues in drug delivery systems.