A Case Report on Giant Carcinoma ex Pleomorphic Adenoma of Submandibular Salivary Gland

Background: Carcinoma ex pleomorphic adenoma (Ca ex PA) is an uncommon but highly aggressive malignancy arising from
long-standing pleomorphic adenomas. Submandibular gland involvement is rare and often associated with delayed diagnosis.
Case Presentation: We report an 83-year-old female with a 50-year history of a slowly enlarging left submandibular mass that
rapidly increased in size during the past two years. Imaging revealed a heterogeneous cystic–solid lesion with coarse
calcifications. Wide local excision was performed, and histopathology confirmed carcinoma ex pleomorphic adenoma.
Medication management included perioperative antibiotics, analgesia, anemia correction, and postoperative supportive therapy.
Conclusion: This case emphasizes the importance of early excision of pleomorphic adenomas to prevent malignant
transformation. Surgery combined with adjuvant radiotherapy offers optimal disease control.
KEYWORDS: Pleomorphic adenoma, Carcinoma ex pleomorphic adenoma, Submandibular gland, Salivary gland malignancy,
Giant tumor