Formulation and evaluation of mucoadhesive microspheres of lisinopril, an antihypertensive drug

Abstract
The objective of this research work is to develop and
evaluate mucoadhesive microspheres of an antihypertensive drug for sustained release. Mucoadhesive
microspheres were prepared by emulsification method
using sodium alginate, HPMC K4M, HPMC K100M,
Na CMC, carbopol 974P and chitosan in the various
drug-polymer ratios. Six formulations were formulated
and evaluated for possible drug polymer interactions,
percentage yield, micromeritic properties, particle
size, drug content, drug entrapment efficiency, drug
loading, swelling index, in vitro wash off test, in vitro
drug release, surface morphology and release kinetics.
The results showed no significant drug polymer
interaction in FTIR studies. Among all the
formulations, F4 containing HPMC K100M showed
99.51% drug release in 24 hrs. Amongst the developed
mucoadhesive microspheres, F4 formulation
containing HPMC K100M exhibited slow and
sustained release in a controlled manner and it is a
promising formulation for sustained release of
Lisinopril.
Keywords: Mucoadhesive Microspheres, HPMCK100M,
Formulations, Evaluations, Sustained release.