Nanodrug Delivery System for Diabetic Foot Ulcer by Solvent Evaporation Method

ABSTRACT
Diabetes may result in severe foot ulcers which normally heal poorly, are characterized by persistent swelling, and
amputation. In our experiment we had a basic mixing and drying procedure involving a fat known as stearic acid and
a soapy-like substance known as soy lecithin to form small solid fat particles. These particles were loaded with
fluoxetine, which is a medication used to treat depression, yet we are utilizing it to make wounds heal. The average
size of the particles was 467nm, quite even, with a surface charge of approximately 32 mv, containing approximately
96 per cent of the drug within them, and 16 per cent by weight drug. The most suitable formulation, which contained
100mg of fluoxetine in a non-crystalline form. Laboratory tests revealed that the drug was released at a slow rate with
approximately 99 percent released within 24 hours by the usual diffusion. This slow was far superior to a simple
fluoxetine gel. The particles were then incorporated into a carbopol gel that was prepared to have a pH that was skin
friendly, easy to spread and squeeze out of a tube. On rats that were diabetized using a chemical known as
streptozotocin, it was found that the new gel was effective in healing diabetic wounds. This achievement demonstrates
the fact that small drug delivery systems can be used to solve the issues, which cause normal drug therapies to fail in
diabetic wounds, including poor blood circulation and risk of infection. The healed wounds had completely healed by
day 28 and tissue examination revealed an increase in collagen-forming protein, an increase in cell growth, an increase
in the number of new blood vessels and an upgrading of collagen formations. This results indicate that small solid fat
particle carriers prepared using this evaporation technique have the potential to deliver active medicines to recalcitrant
diabetic wounds and this presents a plausible avenue towards superior cures of this severe illness.
Keywords: Nanodrug Delivery, Diabetic Foot Ulcer, Solvent Evaporation, Solid Lipid Nanoparticles, Fluoxetine,
Wound Healing.