Formulation, Optimization and Evaluation of Poorly Soluble Drug Snedds

The goal of the study is to increase the oral bioavailability of kaempferol by creating a self-nanoemulsifying drug delivery
system (SNEDDS). In the current work, a variety of oils, surfactants, and co-surfactants were used to manufacture
kaempferol into SNEDDS. Numerous investigations, including droplet size and thermodynamic stability, drug content
analysis, and in vitro drug release experiments, were conducted on the proposed formulations. The combination of
Lauroglycol 90 as the oil phase, Poloxamer 188 as the surfactant, and Transcutol HP as the co-surfactant was chosen for
the creation of SNEDDS of kaempferol after oils, surfactants, and cosurfactants were screened. The pseudo ternary phase diagram was used to optimise the formulation's composition. After evaluation, it was discovered that the optimised formulation had better in vitro drug release and good physical stability. When formulated as a self-nano emulsifying drug delivery system, a stable SNEDDS of kaempferol was created, and the results showed a significant improvement in the drug's dissolution, suggesting that it may improve the medication's oral solubility and bioavailability.