Evaluating The Efficacy And Safety Of Oxycodone And Hydrocodone In Chronic Pain Management With Post Operative Surgical Patient

Chronic post-operative pain is a debilitating condition affecting 10–50% of surgical patients, with opioids like oxycodone
and hydrocodone being primary therapeutic options. This study compared the efficacy, safety, and tolerability of these drugs
in 80 post-operative patients (mean age: 52.4 years) over six months. Oxycodone demonstrated superior pain reduction (Day
30 VAS scores: mean rank 33.21 vs. 48.55 for hydrocodone, *p* < 0.001) and fewer adverse drug reactions (ADRs) (36.3%
reported no ADRs vs. 9% for hydrocodone). Hydrocodone was associated with higher constipation rates (20% vs. 2.4%).
Rescue medications were required by 76.3% of participants, and prolonged use correlated with dependence risk (ρ =
0.658, *p* < 0.001). The findings advocate for personalized opioid selection and multimodal pain management strategies.