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Unlocking the potential of hydrogel microspheres for sustainable environmental remediation

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Published/Copyright: March 11, 2026

Abstract

Contamination of water and soil causes serious damage to the environment as well as public health. Conventional remediation methods have drawbacks such as high cost, complexity, and environmentally harmful. Biodegradable hydrogel microspheres, made of cross-linked polymer networks offer an eco-friendly alternative due to their biocompatibility, water retention, and flexibility. They exhibit improved efficacy in eliminating soil and water contaminants like pesticides, heavy metals and organic dyes through electrostatic, hydrophobic and ion exchange interactions. Nanoparticle encapsulated hydrogels show excellent adsorption, recyclability, and stability. Sustainable agriculture is promoted through hydrogels by retaining nutrients, immobilizing heavy metals, and facilitating controlled pesticide release. In wastewater remediation, hydrogels function by neutralizing germs, remove pollutants, and adsorb greasy contaminants. Biodegradable hydrogels made from natural polymers such as cellulose, gelatin, and starch are significant because of their low toxicity and compatibility. Advanced manufacturing techniques, including microfluidics and 3D printing, have been implemented to optimize hydrogel structure for effective pollutant removal. Overcoming the barrier from laboratory development to field application is essential for finding impactful uses of hydrogel microspheres as adaptive, sustainable technology for global environmental issues. This review focusses on design, synthesis and potential of hydrogels in reducing environmental pollution with special focus on water and soil remediation.


Corresponding author: Perumal Asaithambi, Department of Biotechnology and Chemical Engineering, School of Engineering, Faculty of Science, Technology, and Architecture, Manipal University Jaipur, Jaipur, 303007, Rajasthan, India, e-mail:

  1. Research ethics: Not applicable.

  2. Informed consent: Not applicable.

  3. Author contributions: Meenambiga Setti Sudharsan – Design of work, Data Collection, Drafting and Reviewing the article, Lakshmipriya Selvam – Drafting the article Haripriya Mani – Drafting the article Vivek Pazhamalai – Data collection and analysis, Drafting the article, Hariharan Nattanmai Mothilal – Drafting, Reviewing, Critical revision of the article, Perumal Asaithambi – Reviewing the article for final version.

  4. Use of Large Language Models, AI and Machine Learning Tools: Not applicable.

  5. Conflict of interest: There are no conflicts of interest among the authors.

  6. Research funding: The authors haven’t received any funds from any funding agencies to write this review work.

  7. Data availability: The data that support the findings of this review article are available in public domain resources.

References

1. Alrumman, S.; Keshk, S.; El Kott, A. Water Pollution: Source & Treatment. Am. J. Environ. Eng. 2016, 88–98.Search in Google Scholar

2. Cachada, A.; Rocha-Santos, T.; Duarte, A. C. Soil and Pollution: An Introduction to the Main Issues. InSoil Pollut. 2018, 1, 1–28.10.1016/B978-0-12-849873-6.00001-7Search in Google Scholar

3. Gahrouei, A. E.; Rezapour, A.; Pirooz, M.; Pourebrahimi, S. From Classic to Cutting-Edge Solutions: A Comprehensive Review of Materials and Methods for Heavy Metal Removal from Water Bodies. Desalin. Water Treat. 2024, 100446. https://doi.org/10.1016/j.dwt.2024.100446.Search in Google Scholar

4. Hanafi, M. F.; Sapawe, N. A Review on the Current Techniques and Technologies of Organic Pollutants Removal from Water/Wastewater. Mater. Today: Proc. 2020, 31, A158–65. https://doi.org/10.1016/j.matpr.2021.01.265.Search in Google Scholar

5. Azhar, U.; Ahmad, H.; Shafqat, H.; Babar, M.; Shahzad Munir, H. M.; Sagir, M.; Arif, M.; Hassan, A.; Rachmadona, N.; Rajendran, S.; Mubashir, M.; Khoo, K. S. Remediation Techniques for Elimination of Heavy Metal Pollutants from Soil: A Review. Environ. Res. 2022, 214, 113918. https://doi.org/10.1016/j.envres.2022.113918.Search in Google Scholar PubMed

6. Van Tran, V.; Park, D.; Lee, Y. C. Hydrogel Applications for Adsorption of Contaminants in Water and Wastewater Treatment. Environ. Sci. Pollut. Res. 2018, 25, 24569–99. https://doi.org/10.1007/s11356-018-2605-y.Search in Google Scholar PubMed

7. Mandal, S.; Muralidharan, C.; Mandal, A. B. Water Pollution Remediation Techniques with Special Focus on Adsorption. Adv. Res. Nanosci. Water Technol. 2019, 39–68.10.1007/978-3-030-02381-2_3Search in Google Scholar

8. Garcia-Garcia, A.; Muñana-González, S.; Lanceros-Mendez, S.; Ruiz-Rubio, L.; Alvarez, L. P.; Vilas-Vilela, J. L. Biodegradable Natural Hydrogels for Tissue Engineering, Controlled Release, and Soil Remediation. Polymers 2024, 16 (18), 2599. https://doi.org/10.3390/polym16182599.Search in Google Scholar PubMed PubMed Central

9. Gahrouei, A. E.; Rezapour, A.; Pirooz, M.; Pourebrahimi, S. From Classic to Cutting-Edge Solutions: A Comprehensive Review of Materials and Methods for Heavy Metal Removal from Water Environments. Desalin. Water Treat. 2024, 319, 100446. https://doi.org/10.1016/j.dwt.2024.100446.Search in Google Scholar

10. Adjuik, T. A.; Nokes, S. E.; Montross, M. D. Biodegradability of Bio‐Based and Synthetic Hydrogels as Sustainable Soil Amendments: A Review. J. Appl. Polym. Sci. 2023, 140 (12), e53655. https://doi.org/10.1002/app.53655.Search in Google Scholar

11. Wang, H.; Zhang, Y.; Xiong, J.; Zhang, D.; Lin, H.; Chen, Y. Regenerated Cellulose Microspheres-Aerogel Enabled Sustainable Removal of Metal Ions for Water Remediation. J. Mater. Sci. 2022, 57 (16), 8016–28. https://doi.org/10.1007/s10853-022-07175-y.Search in Google Scholar

12. Romero-Montero, A.; Valencia-Bermúdez, J. L.; Rosas-Meléndez, S. A.; Núñez-Tapia, I.; Piña-Barba, M. C.; Leyva-Gómez, G.; Del Prado-Audelo, M. L. Biopolymeric Fibrous Aerogels: The Sustainable Alternative for Water Remediation. Polymers 2023, 15 (2), 262. https://doi.org/10.3390/polym15020262.Search in Google Scholar PubMed PubMed Central

13. El-Kholy, S. A. Environmentally Benign Freeze Dried Biopolymer-Based Cryogels for Textile Wastewater Treatments: A Review. Int. J. Biol. Macromol. 2024, 18, 133931. https://doi.org/10.1016/j.ijbiomac.2024.133931.Search in Google Scholar PubMed

14. Türkmen, D.; Bakhshpour, M.; Akgönüllü, S.; Aşır, S.; Denizli, A. Heavy Metal Ions Removal from Wastewater Using Cryogels: A Review. Front. Sustain. 2022, 3, 765592. https://doi.org/10.3389/frsus.2022.765592.Search in Google Scholar

15. Lee, K. Y.; Bouhadir, K. H.; Mooney, D. J. Controlled Degradation of Hydrogels Using Multi-Functional Cross-Linking Molecules. Biomaterials 2004, 25, 2461–2466. https://doi.org/10.1016/j.biomaterials.2003.09.030.Search in Google Scholar PubMed

16. Godiya, C. B.; Ruotolo, L. A. M.; Cai, W. Functional Biobased Hydrogels for the Removal of Aqueous Hazardous Pollutants: Current Status, Challenges, and Future Perspectives. J. Mater. Chem. A 2020, 8, 21585–21612. https://doi.org/10.1039/D0TA07028A.Search in Google Scholar

17. Lin, X.; Zhao, X.; Xu, C.; Wang, L.; Xia, Y. Progress in the Mechanical Enhancement of Hydrogels: Fabrication Strategies and Underlying Mechanisms. J. Polym. Sci. 2022, 60, 2525–2542. https://doi.org/10.1002/pol.20220154.Search in Google Scholar

18. Garg, S.; Garg, A.; Vishwavidyalaya, R. D. Hydrogel: Classification, Properties, Preparation and Technical Features. Asian J. Biomater. Res. 2016, 2 (6), 163–70.Search in Google Scholar

19. Liu, Y.; Sui, Y.; Liu, C.; Liu, C.; Wu, M.; Li, B.; Li, Y. A Physically Crosslinked Polydopamine/Nanocellulose Hydrogel as Potential Versatile Vehicles for Drug Delivery and Wound Healing. Carbohydr. Polym. 2018, 188, 27–36. https://doi.org/10.1016/j.carbpol.2018.01.093.Search in Google Scholar PubMed

20. Bustamante-Torres, M.; Pino-Ramos, V. H.; Romero-Fierro, D.; Hidalgo-Bonilla, S. P.; Magaña, H.; Bucio, E. Synthesis and Antimicrobial Properties of Highly Cross-Linked pH-Sensitive Hydrogels Through Gamma Radiation. Polymers 2021, 13 (14), 2223. https://doi.org/10.3390/polym13142223.Search in Google Scholar PubMed PubMed Central

21. Catoira, M. C.; González-Payo, J.; Fusaro, L.; Ramella, M.; Boccafoschi, F. Natural Hydrogels R&D Process: Technical and Regulatory Aspects for Industrial Implementation. J. Mater. Sci.: Mater. Med. 2020, 31 (8), 64. https://doi.org/10.1007/s10856-020-06401-w.Search in Google Scholar PubMed PubMed Central

22. Maddock, R. M.; Pollard, G. J.; Moreau, N. G.; Perry, J. J.; Race, P. R. Enzyme‐Catalysed Polymer Cross‐Linking: Biocatalytic Tools for Chemical Biology, Materials Science and Beyond. Biopolymers 2020, 111 (9), e23390. https://doi.org/10.1002/bip.23390.Search in Google Scholar PubMed

23. Munoz-Munoz, F.; Ruiz, J. C.; Alvarez-Lorenzo, C.; Concheiro, A.; Bucio, E. Temperature-And pH-Sensitive Interpenetrating Polymer Networks Grafted on PP: Cross-Linking Irradiation Dose as a Critical Variable for the Performance as Vancomycin-Eluting Systems. Radiat. Phys. Chem. 2012, 81 (5), 531–40. https://doi.org/10.1016/j.radphyschem.2012.01.007.Search in Google Scholar

24. de Nooy, A. E.; Masci, G.; Crescenzi, V. Versatile Synthesis of Polysaccharide Hydrogels Using the Passerini and Ugi Multicomponent Condensations. Macromolecules 1999, 32 (4), 1318–20. https://doi.org/10.1021/ma9815455.Search in Google Scholar

25. Gulrez, S. K.; Al-Assaf, S.; Phillips, G. O. Progress in Molecular and Environmental Bioengineering – From Analysis and Modeling to Technology Applications (Chap. 5). In Hydrogels: Methods of Preparation, Characterisation and Applications, 2011; pp 126–31.Search in Google Scholar

26. Sperinde, J. J.; Griffith, L. G. Control and Prediction of Gelation Kinetics in Enzymatically Cross-Linked Poly (Ethylene Glycol) Hydrogels. Macromolecules 2000, 33 (15), 5476–80. https://doi.org/10.1021/ma000459d.Search in Google Scholar

27. Ray, D.; Gils, P. S.; Mohanta, G. P.; Manavalan, R.; Sahoo, P. K. Comparative Delivery of Diltiazem Hydrochloride Through Synthesized Polymer: Hydrogel and Hydrogel Microspheres. J. Appl. Polym. Sci. 2010, 116 (2), 959–68. https://doi.org/10.1002/app.31661.Search in Google Scholar

28. Wang, Y.; Burgess, D. J. Influence of Storage Temperature and Moisture on the Performance of Microsphere/Hydrogel Composites. Int. J. Pharm. 2013, 454 (1), 310–5. https://doi.org/10.1016/j.ijpharm.2013.06.012.Search in Google Scholar PubMed

29. Song, M.; Wang, J.; He, J.; Kan, D.; Chen, K.; Lu, J. Synthesis of Hydrogels and their Progress in Environmental Remediation and Antimicrobial Application. Gels 2022, 9 (1), 16. https://doi.org/10.3390/gels9010016.Search in Google Scholar PubMed PubMed Central

30. El Sayed, M. M. Production of Polymer Hydrogel Composites and their Applications. J. Polym. Environ. 2023, 31 (7), 2855–79. https://doi.org/10.1007/s10924-023-02796-z.Search in Google Scholar

31. Shah, L. A.; Khan, M.; Javed, R.; Sayed, M.; Khan, M. S.; Khan, A.; Ullah, M. Superabsorbent Polymer Hydrogels with Good Thermal and Mechanical Properties for Removal of Selected Heavy Metal Ions. J. Clean. Prod. 2018, 201, 78–87. https://doi.org/10.1016/j.jclepro.2018.08.035.Search in Google Scholar

32. Sikdar, P.; Uddin, M. M.; Dip, T. M.; Islam, S.; Hoque, M. S.; Dhar, A. K.; Wu, S. Recent Advances in the Synthesis of Smart Hydrogels. Mater. Adv. 2021, 2 (14), 4532–73. https://doi.org/10.1039/d1ma00193k.Search in Google Scholar

33. Zhang, Y.; Tian, X.; Zhang, Q.; Xie, H.; Wang, B.; Feng, Y. Hydrochar-Embedded Carboxymethyl Cellulose-g-Poly (Acrylic Acid) Hydrogel as Stable Soil Water Retention and Nutrient Release Agent for Plant Growth. J. Bioresour. Bioprod. 2022, 7 (2), 116–27. https://doi.org/10.1016/j.jobab.2022.03.003.Search in Google Scholar

34. Sánchez-Cid, P.; Jiménez-Rosado, M.; Romero, A.; Pérez-Puyana, V. Novel Trends in Hydrogel Development for Biomedical Applications: A Review. Polymers 2022, 14 (15), 3023. https://doi.org/10.3390/polym14153023.Search in Google Scholar PubMed PubMed Central

35. Vinchhi, P.; Rawal, S. U.; Patel, M. M. Biodegradable Hydrogels. In Drug Delivery Devices and Therapeutic Systems; Academic Press: Chapter 19, 2021; pp 395–419.10.1016/B978-0-12-819838-4.00012-2Search in Google Scholar

36. Poppe, J. Gelatin. InThickening and Gelling Agents for Food; Springer: Boston, MA, US, 1992; pp. 98–123.10.1007/978-1-4615-3552-2_5Search in Google Scholar

37. Shyni, K.; Hema, G. S.; Ninan, G.; Mathew, S.; Joshy, C. G.; Lakshmanan, P. T. Isolation and Characterization of Gelatin from the Skins of Skipjack Tuna (Katsuwonus Pelamis), Dog Shark (Scoliodon Sorrakowah), and Rohu (Labeo Rohita). Food Hydrocoll. 2014, 39, 68–76. https://doi.org/10.1016/j.foodhyd.2013.12.008.Search in Google Scholar

38. Mushtaq, F.; Raza, Z. A.; Batool, S. R.; Zahid, M.; Onder, O. C.; Rafique, A.; Nazeer, M. A. Preparation, Properties, and Applications of Gelatin-Based Hydrogels (GHs) in the Environmental, Technological, and Biomedical Sectors. Int. J. Biol. Macromol. 2022, 218, 601–33. https://doi.org/10.1016/j.ijbiomac.2022.07.168.Search in Google Scholar PubMed

39. French, A. D.; Pérez, S.; Bulone, V.; Rosenau, T.; Gray, D. Cellulose. Encyclopedia of Polymer Science and Technology, 4th ed; Copyright © 2002 John Wiley & Sons, Inc., Vol. 1838, 2002; pp 1–69.10.1002/0471440264.pst042.pub2Search in Google Scholar

40. Qin, C. C.; Abdalkarim, S. Y.; Zhou, Y.; Yu, H. Y.; He, X. Ultrahigh Water-Retention Cellulose Hydrogels as Soil Amendments for Early Seed Germination Under Harsh Conditions. J. Clean. Prod. 2022, 370, 133602. https://doi.org/10.1016/j.jclepro.2022.133602.Search in Google Scholar

41. Qamruzzaman, M.; Ahmed, F.; Mondal, M. I. An Overview on Starch-Based Sustainable Hydrogels: Potential Applications and Aspects. J. Polym. Environ. 2022, 30 (1), 19–50. https://doi.org/10.1007/s10924-021-02180-9.Search in Google Scholar

42. Cha, R.; He, Z.; Ni, Y. Preparation and Characterization of Thermal/pH-Sensitive Hydrogel from Carboxylated Nanocrystalline Cellulose. Carbohydr. Polym. 2012, 88 (2), 713–8. https://doi.org/10.1016/j.carbpol.2012.01.026.Search in Google Scholar

43. Kaczmarek, B.; Nadolna, K.; Owczarek, A. The Physical and Chemical Properties of Hydrogels Based on Natural Polymers. Hydrogels Based Nat. Polym. 2020, 1, 151–72.10.1016/B978-0-12-816421-1.00006-9Search in Google Scholar

44. Madduma‐Bandarage, U. S.; Madihally, S. V. Synthetic Hydrogels: Synthesis, Novel Trends, and Applications. J. Appl. Polym. Sci. 2021, 138 (19), 50376. https://doi.org/10.1002/app.50376.Search in Google Scholar

45. Gokhale, D.; Chen, I.; Wu, W. N.; Monne Gagnaire, A.; Doyle, P. S. A Zwitterionic Hydrogel‐Based Heterogeneous Fenton Catalyst for Water Treatment. Small 2024, 20 (38), 2402525. https://doi.org/10.1002/smll.202402525.Search in Google Scholar PubMed

46. Zhang, X.; Arnold, W. A.; Wright, N.; Novak, P. J.; Guest, J. S. Prioritization of Early-Stage Research and Development of a Hydrogel-Encapsulated Anaerobic Technology for Distributed Treatment of High Strength Organic Wastewater. Environ. Sci. Technol. 2024, 58 (44), 19651–65. https://doi.org/10.1021/acs.est.4c05389.Search in Google Scholar PubMed PubMed Central

47. Weerasundara, L.; Gabriele, B.; Figoli, A.; Ok, Y. S.; Bundschuh, J. Hydrogels: Novel Materials for Contaminant Removal in Water – A Review. Crit. Rev. Environ. Sci. Technol. 2021, 51 (17), 1970–2014. https://doi.org/10.1080/10643389.2020.1776055.Search in Google Scholar

48. Piccoli, I.; Camarotto, C.; Squartini, A.; Longo, M.; Gross, S.; Maggini, M.; Cabrera, M. L.; Morari, F. Hydrogels for Agronomical Application: From Soil Characteristics to Crop Growth: A Review. Agron. Sustainable Dev. 2024, 44 (2), 1–23. https://doi.org/10.1007/s13593-024-00958-4.Search in Google Scholar

49. Bwatanglang, I. B.; Musa, Y.; Yusof, N. A. Market Analysis and Commercially Available Cellulose and Hydrogel-Based Composites for Sustainability, Clean Environment, and Human Health. InSustainable Nanocellul. Nanohydrogels Nat. Sources 2020, 1, 65–79.10.1016/B978-0-12-816789-2.00003-1Search in Google Scholar

50. Possidónio, C.; Farias, A. R.; Domingos, S.; Cruz, B.; Luís, S.; Loureiro, A. Exploring Supply-Side Barriers for Commercialization of New Biopolymer Production Technologies: A Systematic Review. Sustainability 2025, 17 (3), 820. https://doi.org/10.3390/su17030820.Search in Google Scholar

51. Hou, X.; Mu, L.; Chen, F.; Hu, X. Emerging Investigator Series: Design of Hydrogel Nanocomposites for the Detection and Removal of Pollutants: From Nanosheets, Network Structures, and Biocompatibility to Machine-Learning-Assisted Design. Environ. Sci.: Nano 2018, 5 (10), 2216–40. https://doi.org/10.1039/c8en00552d.Search in Google Scholar

52. Yang, Q.; Adrus, N.; Tomicki, F.; Ulbricht, M. Composites of Functional Polymeric Hydrogels and Porous Membranes. J. Mater. Chem. 2011, 21 (9), 2783–811. https://doi.org/10.1039/c0jm02234a.Search in Google Scholar

53. Zhu, H.; Fu, Y.; Jiang, R.; Yao, J.; Xiao, L.; Zeng, G. Optimization of Copper (II) Adsorption onto Novel Magnetic Calcium Alginate/Maghemite Hydrogel Beads Using Response Surface Methodology. Ind. Eng. Chem. Res. 2014, 53 (10), 4059–66. https://doi.org/10.1021/ie4031677.Search in Google Scholar

54. Pauletto, P. S.; Gonçalves, J. O.; Pinto, L. A.; Dotto, G. L.; Salau, N. P. Single and Competitive Dye Adsorption onto Chitosan-Based Hybrid Hydrogels Using Artificial Neural Network Modeling. J. Colloid Interface Sci. 2020, 560, 722–9. https://doi.org/10.1016/j.jcis.2019.10.106.Search in Google Scholar PubMed

55. Umar, M.; Khan, H.; Hussain, S.; Arshad, M.; Choi, H.; Lima, E. C. Integrating DFT and Machine Learning for the Design and Optimization of Sodium Alginate-Based Hydrogel Adsorbents: Efficient Removal of Pollutants from Wastewater. Environ. Res. 2024, 247, 118219. https://doi.org/10.1016/j.envres.2024.118219.Search in Google Scholar PubMed

56. Nath, B. K.; Medhi, U.; Deka, R. C.; Kalita, E. Reengineering Agro-Waste-Derived Nanolignin for the Development of Reusable Remediation-Ready Hydrogels. J. Environ. Chem. Eng. 2025, 13 (2), 115831. https://doi.org/10.1016/j.jece.2025.115831.Search in Google Scholar

57. Pereira, R. C.; Anizelli, P. R.; Di Mauro, E.; Valezi, D. F.; da Costa, A. C.; Zaia, C. T.; Zaia, D. A. The Effect of pH and Ionic Strength on the Adsorption of Glyphosate onto Ferrihydrite. Geochem. Trans. 2019, 20, 1–4. https://doi.org/10.1186/s12932-019-0063-1.Search in Google Scholar PubMed PubMed Central

58. Eskandari, S.; Dong, A.; De Castro, L. T.; AB Rahman, F. B.; Lipp, J.; Blom, D. A.; Regalbuto, J. R. Pushing the Limits of Electrostatic Adsorption: Charge Enhanced Dry Impregnation of SBA-15. Catal. Today 2019, 338, 60–71. https://doi.org/10.1016/j.cattod.2019.06.082.Search in Google Scholar

59. Zeng, Q.; Qi, X.; Zhang, M.; Tong, X.; Jiang, N.; Pan, W.; Xiong, W.; Li, Y.; Xu, J.; Shen, J.; Xu, L. Efficient Decontamination of Heavy Metals from Aqueous Solution Using Pullulan/Polydopamine Hydrogels. Int. J. Biol. Macromol. 2020, 145, 1049–58. https://doi.org/10.1016/j.ijbiomac.2019.09.197.Search in Google Scholar PubMed

60. Saber-Samandari, S.; Saber-Samandari, S.; Gazi, M. Cellulose-Graft-Polyacrylamide/Hydroxyapatite Composite Hydrogel with Possible Application in Removal of Cu (II) Ions. React. Funct. Polym. 2013, 73 (11), 1523–30. https://doi.org/10.1016/j.reactfunctpolym.2013.07.007.Search in Google Scholar

61. Wawrzkiewicz, M.; Hubicki, Z. Anion Exchange Resins as Effective Sorbents for Removal of Acid, Reactive, and Direct Dyes from Textile Wastewaters. Ion Exch.:Stud. Appl. 2015, 9, 37–72.10.5772/60952Search in Google Scholar

62. Rodrigues, F. H.; de Magalhães, C. E. C.; Medina, A. L.; Fajardo, A. R.; Fajardo, A. R. Hydrogel Composites Containing Nanocellulose as Adsorbents for Aqueous Removal of Heavy Metals: Design, Optimization, and Application. Cellulose 2019, 26, 9119–33. https://doi.org/10.1007/s10570-019-02736-y.Search in Google Scholar

63. Van Oss, C. J.; Good, R. J.; Chaudhury, M. K. The Role of Van der Waals Forces and Hydrogen Bonds in “Hydrophobic Interactions” Between Biopolymers and Low Energy Surfaces. J. Colloid Interface Sci. 1986, 111 (2), 378–90. https://doi.org/10.1016/0021-9797(86)90041-x.Search in Google Scholar

64. Tokuyama, H.; Iwama, T. Temperature-Swing Solid-Phase Extraction of Heavy Metals on a Poly (N-isopropylacrylamide) Hydrogel. Langmuir 2007, 23 (26), 13104–8. https://doi.org/10.1021/la701728n.Search in Google Scholar PubMed

65. Tran, T. H.; Okabe, H.; Hidaka, Y.; Hara, K. Removal of Metal Ions from Aqueous Solutions Using Carboxymethyl Cellulose/Sodium Styrene Sulfonate Gels Prepared by Radiation Grafting. Carbohydr. Polym. 2017, 157, 335–43. https://doi.org/10.1016/j.carbpol.2016.09.049.Search in Google Scholar PubMed

66. Aly, A. A.; El-Bisi, M. K. Grafting of Polysaccharides: Recent Advances. In Biopolym. Grafting; Elsevier: Amsterdam, The Netherlands, 2018; pp. 469–519.10.1016/B978-0-323-48104-5.00011-1Search in Google Scholar

67. Luo, R.; Li, H. A Modeling Study of the Effect of Environmental Ionic Valence on the Mechanical Characteristics of pH–Electrosensitive Hydrogel. Acta Biomater. 2009, 5 (8), 2920–8. https://doi.org/10.1016/j.actbio.2009.04.009.Search in Google Scholar PubMed

68. Bassett, D. C.; Håti, A. G.; Melø, T. B.; Stokke, B. T.; Sikorski, P. Competitive Ligand Exchange of Crosslinking Ions for Ionotropic Hydrogel Formation. J. Mater. Chem. B 2016, 4 (37), 6175–82. https://doi.org/10.1039/c6tb01812b.Search in Google Scholar PubMed

69. Dong, S.; Wang, Y.; Li, J.; Zhang, D.; Zhou, Y.; Tong, Y. Tuning the Crosslink Structure of Cationic Hydrogel for Enhanced Chromium (VI) Removal: The Covalent and Electrostatic Co-Crosslinked Effects and Adsorption Mechanism. Chem. Eng. J. 2020, 394, 124944. https://doi.org/10.1016/j.cej.2020.124944.Search in Google Scholar

70. Li, J.; Dong, S.; Wang, Y.; Dou, X.; Hao, H. Nitrate Removal from Aqueous Solutions by Magnetic Cationic Hydrogel: Effect of Electrostatic Adsorption and Mechanism. J. Environ. Sci. 2020, 91, 177–88. https://doi.org/10.1016/j.jes.2020.01.029.Search in Google Scholar PubMed

71. Astrini, N.; Anah, L.; Haryadi, H. R. Adsorption of Heavy Metal Ion from Aqueous Solution by Using Cellulose Based Hydrogel Composite. Macromol. Symp. 2015, 353 (1), 191–197. https://doi.org/10.1002/masy.201550326.Search in Google Scholar

72. Kwak, H. W.; Shin, M.; Yun, H.; Lee, K. H. Preparation of Silk Sericin/Lignin Blend Beads for the Removal of Hexavalent Chromium Ions. Int. J. Mol. Sci. 2016, 17 (9), 1466. https://doi.org/10.3390/ijms17091466.Search in Google Scholar PubMed PubMed Central

73. Kim, M. K.; Shanmuga Sundaram, K.; Anantha Iyengar, G.; Lee, K. P. A Novel Chitosan Functional Gel Included with Multiwall Carbon Nanotube and Substituted Polyaniline as Adsorbent for Efficient Removal of Chromium Ion. Chem. Eng. J. 2015, 267, 51–64. https://doi.org/10.1016/j.cej.2014.12.091.Search in Google Scholar

74. Maity, J.; Ray, S. K. Removal of Cu (II) Ion from Water Using Sugar Cane Bagasse Cellulose and Gelatin Based Composite Hydrogels. Int. J. Biol. Macromol. 2017, 97, 238–48. https://doi.org/10.1016/j.ijbiomac.2017.01.011.Search in Google Scholar PubMed

75. Hara, K.; Iida, M.; Yano, K.; Nishida, T. Metal Ion Absorption of Carboxymethylcellulose Gel Formed by γ-Ray Irradiation: For the Environmental Purification. Colloids Surf., B 2004, 38 (3–4), 227–30. https://doi.org/10.1016/j.colsurfb.2004.02.024.Search in Google Scholar PubMed

76. Tang, H.; Chang, C.; Zhang, L. Efficient Adsorption of Hg2+ Ions on Chitin/Cellulose Composite Membranes Prepared via Environmentally Friendly Pathway. Chem. Eng. J. 2011, 173 (3), 689–97. https://doi.org/10.1016/j.cej.2011.07.045.Search in Google Scholar

77. Sanyang, M. L.; Ghani, W. A.; Idris, A.; Ahmad, M. B. Hydrogel Biochar Composite for Arsenic Removal from Wastewater. Desalin. Water Treat. 2016, 57 (8), 3674–88. https://doi.org/10.1080/19443994.2014.989412.Search in Google Scholar

78. Seida, Y.; Tokuyama, H. Hydrogel Adsorbents for the Removal of Hazardous Pollutants – Requirements and Available Functions as Adsorbent. Gels 2022, 8 (4), 220. https://doi.org/10.3390/gels8040220.Search in Google Scholar PubMed PubMed Central

79. Liang, L.; Yang, X.; Liang, X.; Lin, X.; Zhang, H.; Pang, C.; Pan, X.; Hu, Y.; Chen, Y.; Luo, X. Synergistic Improvement of Mechanical and Adsorption Properties by Constructing Physical Multiple-Network Hydrogel for Removing Uranium. J. Mol. Struct. 2024, 1298, 137046. https://doi.org/10.1016/j.molstruc.2023.137046.Search in Google Scholar

80. Zhang, J.; Fu, K.; Wang, D.; Zhou, S.; Luo, J. Refining Hydrogel-Based Sorbent Design for Efficient Toxic Metal Removal Using Machine Learning-Bayesian Optimization. J. Hazard. Mater. 2024, 479, 135688. https://doi.org/10.1016/j.jhazmat.2024.135688.Search in Google Scholar PubMed

81. Wong, S. K.; Lawrencia, D.; Supramaniam, J.; Goh, B. H.; Manickam, S.; Wong, T. W.; Pang, C. H.; Tang, S. Y. In Vitro Digestion and Swelling Kinetics of Thymoquinone-Loaded Pickering Emulsions Incorporated in Alginate-Chitosan Hydrogel Beads. Front. Nutr. 2021, 8, 752207. https://doi.org/10.3389/fnut.2021.752207.Search in Google Scholar PubMed PubMed Central

82. Zong, P.; Chen, J.; Yang, Y.; Qiu, Z.; Xu, M.; Guo, L.; Lv, X.; Wang, S. Outstanding Performance of Core–Shell Structured Chitosan-Sodium Alginate Decorated ZIF-90 Beads for the Synchronous Purification of Pb and Co from Industrial Effluents. Sep. Purif. Technol. 2024, 331, 125663. https://doi.org/10.1016/j.seppur.2023.125663.Search in Google Scholar

83. Zhou, G.; Liu, C.; Chu, L.; Tang, Y.; Luo, S. Rapid and Efficient Treatment of Wastewater with High-Concentration Heavy Metals Using a New Type of Hydrogel-Based Adsorption Process. Bioresour. Technol. 2016, 219, 451–7. https://doi.org/10.1016/j.biortech.2016.07.038.Search in Google Scholar PubMed

84. Chen, Y.; Wang, T.; Liu, J.; Huang, J.; Zhou, G.; Hu, S. Synthesis of Microgel‐Reinforced Double Network Hydrogel Adsorbent and its Adsorption on Heavy Metals. J. Chem. Technol. Biotechnol. 2023, 98 (5), 1260–8. https://doi.org/10.1002/jctb.7343.Search in Google Scholar

85. Medeiros, S. F.; Oliveira, P. F.; Silva, T. M.; Lara, B. R.; Elaissari, A.; Santos, A. M. Biocompatible and Multi-Responsive Poly (N-Vinylcaprolactam)-Based Microgels: The Role of Acidic Comonomers in the Colloidal Properties and Phase Transition as a Function of Temperature and pH. Eur. Polym. J. 2015, 73, 191–201. https://doi.org/10.1016/j.eurpolymj.2015.10.008.Search in Google Scholar

86. Ambreen, J.; Al-Harbi, F. F.; Sakhawat, H.; Ajmal, M.; Naeem, H.; Farooqi, Z. H.; Batool, N.; Siddiq, M. Fabrication of Poly (N-Vinylcaprolactam-Co-Acrylic Acid)-Silver Nanoparticles Composite Microgel with Substantial Potential of Hydrogen Peroxide Sensing and Catalyzing the Reduction of Water Pollutants. J. Mol. Liq. 2022, 355, 118931. https://doi.org/10.1016/j.molliq.2022.118931.Search in Google Scholar

87. Wi, E.; Go, S.; Phu, N. A.; Seong Kim, K.; Lee, H.; Ko, Y.; Yoon, H.; Ranjan Singha, N.; Chang, M. Efficient Recovery of Cr (VI), Au (III), and Pd (II) Using Physically Crosslinked Aminoclay/Polyvinyl Alcohol Composite Microgels Generated by Microfluidics. Sep. Purif. Technol. 2024, 344, 127308. https://doi.org/10.1016/j.seppur.2024.127308.Search in Google Scholar

88. Otey, F. H.; Trimnell, D.; Westhoff, R. P.; Shasha, B. S. Starch Matrix for Controlled Release of Urea Fertilizer. J. Agric. Food Chem. 1984, 32 (5), 1095–8. https://doi.org/10.1021/jf00125a041.Search in Google Scholar

89. Abdul Khalil, H. P.; Jha, K.; Yahya, E. B.; Panchal, S.; Patel, N.; Garai, A.; Kumari, S.; Jameel, M. Insights into the Potential of Biopolymeric Aerogels as an Advanced Soil-Fertilizer Delivery Systems. Gels 2023, 9 (8), 666. https://doi.org/10.3390/gels9080666.Search in Google Scholar PubMed PubMed Central

90. Li, Z.; Zhang, M. Progress in the Preparation of Stimulus-Responsive Cellulose Hydrogels and their Application in Slow-Release Fertilizers. Polymers 2023, 15 (17), 3643. https://doi.org/10.3390/polym15173643.Search in Google Scholar PubMed PubMed Central

91. Saberi Riseh, R.; Hassanisaadi, M.; Vatankhah, M.; Varma, R. S.; Thakur, V. K. Nano/Micro-Structural Supramolecular Biopolymers: Innovative Networks with the Boundless Potential in Sustainable Agriculture. Nano-Micro Lett. 2024, 16 (1), 147. https://doi.org/10.1007/s40820-024-01348-x.Search in Google Scholar PubMed PubMed Central

92. Maksimova, Y. G.; Shchetko, V. A.; Maksimov, A. Y. Polymer Hydrogels in Agriculture. Sel’skokhozyaistvennaya Biol. 2023, 58, 23–42.10.15389/agrobiology.2023.1.23engSearch in Google Scholar

93. Fu, J.; Yap, J. X.; Leo, C. P.; Chang, C. K.; Show, P. L. Polysaccharide Hydrogels for Controlling the Nutrient Release. Sep. Purif. Rev. 2024, 53 (3), 276–88. https://doi.org/10.1080/15422119.2023.2269395.Search in Google Scholar

94. Garduque, R. G.; Gococo, B. J.; Yu, C. A.; Nalzaro, P. J.; Tumolva, T. Synthesis and Characterization of Sodium Carboxymethyl Cellulose/Sodium Alginate/Hydroxypropyl Cellulose Hydrogel for Agricultural Water Storage and Controlled Nutrient Release. Solid State Phenom. 2020, 304, 51–57. https://doi.org/10.4028/www.scientific.net/ssp.304.51.Search in Google Scholar

95. Hou, X.; Pan, Y.; Xiao, H.; Liu, J. Controlled Release of Agrochemicals Using pH and Redox Dual-Responsive Cellulose Nanogels. J. Agric. Food Chem. 2019, 67 (24), 6700–7. https://doi.org/10.1021/acs.jafc.9b00536.Search in Google Scholar PubMed

96. Dhiman, A.; Sharma, A. K.; Bhardwaj, D.; Agrawal, G. Biodegradable Dual Stimuli Responsive Alginate Based Microgels for Controlled Agrochemicals Release and Soil Remediation. Int. J. Biol. Macromol. 2023, 228, 323–32. https://doi.org/10.1016/j.ijbiomac.2022.12.225.Search in Google Scholar PubMed

97. Thombare, N.; Mishra, S.; Siddiqui, M. Z.; Jha, U.; Singh, D.; Mahajan, G. R. Design and Development of Guar Gum Based Novel, Superabsorbent and Moisture Retaining Hydrogels for Agricultural Applications. Carbohydr. Polym. 2018, 185, 169–78. https://doi.org/10.1016/j.carbpol.2018.01.018.Search in Google Scholar PubMed

98. Xue, D.; Li, T.; Liu, Y.; Yang, Y.; Zhang, Y.; Cui, J.; Guo, D. Selective Adsorption and Recovery of Precious Metal Ions from Water and Metallurgical Slag by Polymer Brush Graphene–Polyurethane Composite. React. Funct. Polym. 2019, 136, 138–52. https://doi.org/10.1016/j.reactfunctpolym.2018.12.026.Search in Google Scholar

99. Deng, Z.; Oraby, E. A.; Eksteen, J. J. Cu Adsorption Behaviours onto Chelating Resins from Glycine-Cyanide Solutions: Isotherms, Kinetics and Regeneration Studies. Sep. Purif. Technol. 2020, 236, 116280. https://doi.org/10.1016/j.seppur.2019.116280.Search in Google Scholar

100. Tong, Y.; McNamara, P. J.; Mayer, B. K. Adsorption of Organic Micropollutants onto Biochar: A Review of Relevant Kinetics, Mechanisms and Equilibrium. Environ. Sci.: Water Res. Technol. 2019, 5 (5), 821–38. https://doi.org/10.1039/c8ew00938d.Search in Google Scholar

101. Parasuraman, D.; Serpe, M. J. Poly (N-isopropylacrylamide) Microgel-Based Assemblies for Organic Dye Removal from Water. ACS Appl. Mater. Interfaces 2011, 3 (12), 4714–21. https://doi.org/10.1021/am201132x.Search in Google Scholar PubMed

102. Naseem, K.; Begum, R.; Wu, W.; Irfan, A.; Farooqi, Z. H. Advancement in Multi-Functional Poly (Styrene)-poly (N-isopropylacrylamide) Based Core–Shell Microgels and their Applications. Polym. Rev. 2018, 58 (2), 288–325. https://doi.org/10.1080/15583724.2017.1423326.Search in Google Scholar

103. Kubiak, A.; Maćkiewicz, M.; Biesaga, M.; Karbarz, M. Highly Efficient Removal of Bisphenols from Aqueous Solution Using Environmental-Sensitive Microgel. J. Environ. Chem. Eng. 2021, 9 (1), 104947. https://doi.org/10.1016/j.jece.2020.104947.Search in Google Scholar

104. Al-Ghouti, M. A.; Da’ana, D. A. Guidelines for the Use and Interpretation of Adsorption Isotherm Models: A Review. J. Hazard. Mater. 2020, 393, 122383. https://doi.org/10.1016/j.jhazmat.2020.122383.Search in Google Scholar PubMed

105. Zhao, B.; Jiang, H.; Lin, Z.; Xu, S.; Xie, J.; Zhang, A. Preparation of Acrylamide/Acrylic Acid Cellulose Hydrogels for the Adsorption of Heavy Metal Ions. Carbohydr. Polym. 2019, 224, 115022. https://doi.org/10.1016/j.carbpol.2019.115022.Search in Google Scholar PubMed

106. Subhan, H.; Alam, S.; Shah, L. A.; Khattak, N. S.; Zekker, I. Sodium Alginate Grafted Hydrogel for Adsorption of Methylene Green and Use of the Waste as an Adsorbent for the Separation of Emulsified Oil. J. Water Process Eng. 2022, 46, 102546. https://doi.org/10.1016/j.jwpe.2021.102546.Search in Google Scholar

107. Alver, E.; Metin, A. Ü.; Brouers, F. Methylene Blue Adsorption on Magnetic Alginate/Rice Husk Bio-Composite. Int. J. Biol. Macromol. 2020, 154, 104–13. https://doi.org/10.1016/j.ijbiomac.2020.02.330.Search in Google Scholar PubMed

108. La, Y. H.; McCloskey, B. D.; Sooriyakumaran, R.; Vora, A.; Freeman, B.; Nassar, M.; Hedrick, J.; Nelson, A.; Allen, R. Bifunctional Hydrogel Coatings for Water Purification Membranes: Improved Fouling Resistance and Antimicrobial Activity. J. Membr. Sci. 2011, 372 (1–2), 285–91. https://doi.org/10.1016/j.memsci.2011.02.005.Search in Google Scholar

109. Crini, G. Non-Conventional Low-Cost Adsorbents for Dye Removal: A Review. Bioresour. Technol. 2006, 97 (9), 1061–1085. https://doi.org/10.1016/j.biortech.2005.05.001.Search in Google Scholar PubMed

110. Dahiya, S.; Katakojwala, R.; Ramakrishna, S.; Mohan, S. V. Biobased Products and Life Cycle Assessment in the Context of Circular Economy and Sustainability. Mater. Circular Economy 2020, 2 (1), 1–28. https://doi.org/10.1007/s42824-020-00007-x.Search in Google Scholar

111. Mannan, M.; Al-Ghamdi, S. G. Complementing Circular Economy with Life Cycle Assessment: Deeper Understanding of Economic, Social, and Environmental Sustainability. In Circular Economy and Sustainability; Elsevier, 2022; pp. 145–160.10.1016/B978-0-12-819817-9.00032-6Search in Google Scholar

112. Tang, S. C.; Yan, D. Y.; Lo, I. M. Sustainable Wastewater Treatment Using Microsized Magnetic Hydrogel with Magnetic Separation Technology. Ind. Eng. Chem. Res. 2014, 53 (40), 15718–15724. https://doi.org/10.1021/ie502512h.Search in Google Scholar

113. Brusseau, M. L. Sustainable Development and Other Solutions to Pollution and Global Change. In Environmental and Pollution Science; Academic Press, 2019; pp. 585–603.10.1016/B978-0-12-814719-1.00032-XSearch in Google Scholar

Received: 2025-11-27
Accepted: 2026-01-29
Published Online: 2026-03-11

© 2026 IUPAC & De Gruyter

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