The Multifaceted Challenge of Ulcerative Colitis: A Review
Jayaprakash Sagayaraj, Monisha and S, Theyshnee (2025) The Multifaceted Challenge of Ulcerative Colitis: A Review. In: Interdisciplinary Approaches to Science and Management for Innovative Development. Scientific Research Reports, CHENNAI, pp. 159-172. ISBN ISBN: 978-81-987134-5-2
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Abstract
Ulcerative colitis (UC) is a chronic inflammation of the colon and rectum, arising from a mix of genetic, environmental, and immune factors. Though its precise origins remain unclear, current therapies aim beyond
symptom relief toward full mucosal healing. Modern treatment includes mesalamines, corticosteroids, biologics, and novel agents like JAK inhibitors and IL-23 blockers. However, severe and refractory cases often require surgical intervention. In parallel, this study explored Nubia
red garlic (Allium sativum L.) for its therapeutic potential in UC. Using an ex vivo model of LPS-induced colon inflammation in mice, both hydroalcoholic (GHE) and water-based (GWE) garlic extracts showed strong anti-inflammatory effects—significantly reducing COX-2, TNF-α, NF-κB, and IL-6 expression. They also lowered oxidative damage and
improved serotonin turnover, especially with GHE. These actions are linked to polyphenols such as catechin, quercetin, and benzoic acid.
| Item Type: | Book Section |
|---|---|
| Subjects: | Pharmaceutics > Drug Delivery System |
| Domains: | Agriculture Pharmaceutics |
| Depositing User: | Mr IR Admin |
| Date Deposited: | 10 May 2026 11:25 |
| Last Modified: | 14 May 2026 12:59 |
| URI: | https://ir.vistas.ac.in/id/eprint/14988 |
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