"CRAFTING SMARTER SEDDS: A DOE-DRIVEN APPROACH"

Jayaprakash Sagayaraj, Monisha and K, Monika (2025) "CRAFTING SMARTER SEDDS: A DOE-DRIVEN APPROACH". In: AI-driven Innovations in Drug Discovery & Emerging Technologies in Pharmacy – A Global Perspective, 4-6 august 2026, C.L. Baid Metha Auditorium in Chennai, India. (In Press)

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Abstract

Self-Emulsifying Drug Delivery Systems (SEDDS) enhance the solubility and oral
bioavailability of poorly water-soluble drugs by forming oil-in-water emulsions in the
gastrointestinal tract. Composed of oils, surfactants, and co-surfactants, SEDDS bypass the
need for a dissolution step, improving drug absorption. Design of Experiments (DoE) offers
a systematic and efficient approach to optimize critical formulation variables such as oil
type, surfactant ratio, and drug loading. Common DoE methods like Box-Behnken and
central composite designs help evaluate key performance indicators such as droplet size,
zeta potential, and drug release. By reducing trial-and-error, DoE accelerates development,
minimizes material use, and aligns with Quality by Design (QbD) principles, ultimately
resulting in robust and patient-friendly drug formulations

Item Type:	Conference or Workshop Item (Keynote)
Subjects:	Pharmaceutics > Drug Delivery System
Domains:	Pharmaceutics
Depositing User:	Mr IR Admin
Date Deposited:	10 May 2026 10:55
Last Modified:	14 May 2026 13:04
URI:	https://ir.vistas.ac.in/id/eprint/14960

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