Design And Evaluation Of A Sustained-Release Amla Formulation For Long- Term Prevention Of Scurvy

Long-term vitamin C deficiency is the cause of scurvy, a nutritional deficiency disorder that manifests as bleeding gums,
exhaustion, poor wound healing and anemia. Amla (Emblica officinalis) has potent antioxidant qualities and is well-known
natural source of ascorbic acid (vitamin C). however, frequent administration of ascorbic acid (vitamin C) is required due
to its short biological half-life and poor stability. The current study intends to develop and assess a sustained release
formulation of amla extract for the long-term prevention of scurvy in order to get around these restrictions. In this study,
sodium alginate and Carbopol 934 were used as polymers to prepare amla extract and incorporate it into a sustained release
hydrogel system. Calcium chloride was used for cross-linking in order to improve gel strength and regulate drug release.
The prepared formulation was assessed for stability, invitro drug release, drug content, swelling behaviour and gel
strength. Effective sustained release behaviour was indicated by the results which showed controlled and prolonged release
of vitamin C over an extended period. The formulation remained stable under the specified storage conditions according
to stability studies. A viable, all-natural and patient-friendly method for sustaining therapeutic vitamin C levels and
averting scurvy over an extended period of time is the developed sustained release amla formulation