Ophthalmic in-Situ Gel for Enhanced Drug Delivery: Formulation and Evaluation

This study aims to develop and evaluate a pH-triggered
in-situ gel containing prednisolone and moxifloxacin to overcome
the limitations of conventional eye drops, such as low
bioavailability due to lacrimal drainage. The Formulation utilised
Carbopol 940 as a crosslinked polyacrylic acid polymer and HPMC
as a mucoadhesive agent to enhance viscosity. Buffering agents
adjusted the pH to 6.5, enabling sol to gel transition upon contact
with the ocular environment. Key Parameters such as clarity, pH,
gelation temperature, spreadability and drug content were assessed.
The optimized formulation demonstrated desirable transparency,
gelation behaviour, and sustained drug release, offering improved
stability, reduced irritation, and enhanced therapeutic efficacy
compared to standard eye drops.