Repurposing Ropinirole HCl for Targeting Breast Cancer: Preparation and Characterization of Liposomal Formulation Based on QBD Approach

Repurposing Ropinirole HCl for Targeting Breast Cancer: Preparation and Characterization of Liposomal Formulation Based on QBD Approach School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advance Studies(VISTAS), Pallavaram, Chennai, India Sebastine Chinnamma A Mohamed Zerein Fathima M School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advance Studies(VISTAS), Pallavaram, Chennai, India

Breast cancer remains a leading cause of cancer-related mortality worldwide, necessitating the development of novel therapeutic strategies. Ropinirole HCl, a dopamine receptor agonist primarily used for Parkinson's disease, has shown potential anticancer activity by modulating dopamine receptors, inhibiting angiogenesis, and inducing apoptosis in breast cancer cells. This study aims to formulate and optimize a liposomal delivery system for Ropinirole HCl using the Quality by Design (QbD) approach. A Box-Behnken design was employed to evaluate the effects of lipid concentration, stabilizer concentration, and homogenization speed on critical quality attributes, including particle size, zeta potential, and polydispersity index (PDI). The ideal combination (F12) was 75.8 nm in size, -38.6 mV in surface charge, and 0.559 in PDI, meaning that it is more stable and more suitable as a targeted drug carrier. These findings indicate the fact that liposomal Ropinirole HCl can become an excellent method of breast cancer treatment.
2025 01 13 10.25258/ijddt.15.2.47 https://impactfactor.org/PDF/IJDDT/15/IJDDT,Vol15,Issue2,Article47.pdf