Maceration, phytochemical screening, and in vivo neuro-pharmacological evaluations of Rynchotechum Ellipticum acetone fraction in Swiss albino mice

Rhynchotechum ellipticum, locally known as Cheodhima,
Paicha, or Sattari, is a traditional medicinal plant used to
treat various diseases. This study aimed to evaluate the
neuropharmacological effects of R. ellipticum leaf and stem
extracts in Swiss albino mice. In the thiopental sodiuminduced sleeping time test, mice received different doses of
25, 50, 100, and 200 mg/kg body weight, while 50 and 125
mg/kg body weight were used in other examinations. In
trials examining the effects of thiopental sodium on sleep,
administration of the extracts caused a marked reduction in
the amount of time spent sleeping and the time needed to
fall asleep (p<0.05, p<0.01, and p<0.001). Additionally, at
doses of 50 and 125 mg/kg, a significant decrease in
unrestricted movement and exploratory behavior was
observed in both the hole-crossing and open-field tests
(p<0.05, p<0.01, and p<0.001). The hole-board test also
decreased the frequency of head dips at doses of 50 mg/kg
and 125 mg/kg (p<0.05, p<0.01, and p<0.001). Both
extracts demonstrated superior neuropharmacological
properties at a dose of 125 mL/kg. The leaf and stem
extracts of R. ellipticum have potent anti-depressant and
hypnotic effects on the central nervous system, and could
be utilized in neuropharmacology as an additional therapy.