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ABSTRACT:
The major problem facing the investigators is targeted drug delivery to specific sites. The emergence of a new nanoparticles carriers known as nanosponges should address these problems. Nanosponge is a novel and arising innovation that provides for topical use controlled substance delivery. The implementation of nanosponges, its prep techniques, and assessment were addressed in this review paper. Nano-sponges play a crucial role in the controlled delivery of drugs. To guide drug delivery a wide range of drugs could be packed into nanosponge. All lipophilic and hydrophilic medicinal products could be loaded into nanosponges. The drug delivery system Nanosponge has appeared to be one of life modern science many successful sectors.
KEYWORDS: Nanosponges, topical application, targeted drug delivery, controlled drug delivery, colloidal carrier, Emulsion Solvent Diffusion Method.
INTRODUCTION:
Targeted drug delivery systems have been an undertaking for a long period of time to achieve the expected outcome. In the start, the drug delivery method of Nanosponge emerged only as a topical delivery system, but in the 21st century, both oral and intravenous (IV) route can be used to administer nanosponges[1]. Nanosponge is a traditional component group consisting of small particles with several nanometers narrow cavity. There are different types of materials that can fill these small cavities[2].Nanosponges are a 3D scaffold or polyester network that can naturally degrade. In a mixture to form nanosponges, these polyesters are blended with a crosslinker. The polyester is typically environmentally friendly here, so it starts to break down gradually in the body. When the nanosponges scaffold dissolves, it exposes the loaded drug molecules in a pejorative way.
Many of the developments made using nanomedicine are ·
1. Production of one dose per day of ciprofloxacin
2. Tumor guided taxol delivery[3]
3. Enhanced ophthalmic delivery utilizing wise hydrogel nanoparticles[4]
4. Oral insulin formulation using nanoparticles[5]
5. Liposomal-based amphotericin B formulation
Some of the major benefits of this method is reliable release relative to other nanoparticle delivery systems under growth. Many other delivery systems of nanoparticles unload many of their drug in quick and unpredictable fashion when they hit their target. It is termed the burst effect, making it hard difficult to establish successful dosage levels, while nanosponges are difficult to determine when they hit their target. Controlled release of...
